Computational Systems Biology of Cancer

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9781439831441: Computational Systems Biology of Cancer
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The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models―integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools.

Novel Approaches to Fighting Cancer
Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research.

Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications
Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects:

  1. Categorising tumours
  2. Finding new targets
  3. Designing improved and tailored therapeutic strategies

Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.

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Recensione:

"There is a tremendous amount of biological and biochemical detail in this book, and yet (gratifyingly and perhaps surprisingly) considerable attention is paid to mathematical definitions ..."
―John Adam, Mathematical Reviews, August 2013

"An up-to-date, comprehensive and very readable overview, this book has plenty for everyone interested in computational systems biology of cancer. Almost all important topics are introduced and explained, and pointers are given to further work. The bibliography is outstanding. Think of this as your guide book to the field, as well as a way to get started in it."
―Terry Speed, Professor of Statistics, University of California, Berkeley, USA, and Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

"This book deals with an important and very timely topic: The ongoing struggle against cancer can benefit greatly from the novel high-throughput technologies that are rapidly becoming more accessible. However, in order to make effective use of the data that these technologies produce, sophisticated computational methods that address the cancer disease on the system level are needed. The authors have made substantial and useful effort to describe the state of the art of these computational methods in an accessible and clear way. The book is a much-needed contribution to modern cancer analysis and to the emerging discipline of systems biology."
―Ron Shamir, Professor of Bioinformatics, Tel Aviv University, Israel

"This is the first book specifically focused on computational systems biology of cancer with coherent and proper vision on how to tackle this formidable challenge. I would like to congratulate the authors for their visions and dedications."
―Hiroaki Kitano, President, The Systems Biology Institute; President and Chief Operating Officer, Sony Computer Science Laboratories, Inc.; and Professor, Okinawa Institute of Science and Technology, Japan

L'autore:

Emmanuel Barillot, Laurence Calzone, Philippe Hupe, Jean-Philippe Vert, and Andrei Zinovyev are all with the Institut Curie in Paris, France.

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Emmanuel Barillot; Laurence Calzone; Philippe Hupe; Jean-Philippe Vert; Andrei Zinovyev
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Barillot, Emmanuel; Calzone, Laurence; Hupe, Philippe; Vert, Jean-Philippe; Zinovyev, Andrei
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BARILLOT, EMMANUEL; CALZONE, LAURENCE; HUPE, PHILIPPE; VERT, JEAN-PHILIPPE ; ZINOVYEV, ANDREI.
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Descrizione libro CRC Press, 2012. Hardback. Condizione: NEW. 9781439831441 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. For all enquiries, please contact Herb Tandree Philosophy Books directly - customer service is our primary goal. Codice articolo HTANDREE0185526

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Emmanuel Barillot; Laurence Calzone; Philippe Hupe; Jean-Philippe Vert; Andrei Zinovyev
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Descrizione libro Taylor Francis Inc, United States, 2012. Hardback. Condizione: New. New. Language: English . This book usually ship within 10-15 business days and we will endeavor to dispatch orders quicker than this where possible. Brand New Book. The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models-integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: * Categorising tumours * Finding new targets * Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at. Codice articolo BTE9781439831441

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Descrizione libro CRC Pr I Llc, 2012. Hardcover. Condizione: Brand New. 1st edition. 423 pages. 9.75x6.50x1.00 inches. In Stock. Codice articolo __1439831440

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