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Basics of Pet Imaging: Physics, Chemistry, and Regulations - Brossura

 
9781441919441: Basics of Pet Imaging: Physics, Chemistry, and Regulations

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Sinossi

This book is an ideal text on PET imaging technology that focuses on the basics, such as physics, instrumentation, production of PET radionuclides and radiopharmaceuticals, and regulations affecting PET. The chapters are concise but comprehensive, making the topic easily understandable, and they are complete with reviews of pertinent basic science and lists of suggested reading. Practical tables and appendixes contain a wealth of valuable data, reflecting the book's usefulness as a reference for nuclear medicine professionals, including physicians, residents, and technologists. The book also benefits technologists and residents preparing for board examinations because of its brevity and clarity of content.

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Recensione

From the reviews: "Gives a clear and concise overview of basic physics and PET instrumentation, the theory of image processing and attenuation correction, scanner performance and testing, cyclotron production and synthesis of PET radiopharmaceuticals ... . These subjects are not often covered in a single volume and make the book useful ... . up to date as possible in a rapidly evolving field ... . The question and answer sections at the end of each chapter would be an aid in self-learning." (M J Myers, RAD Magazine, July, 2005) "This book presents the fundamentals of PET imaging in a very practical and concise, but also exhaustive way. ... The book is very informative and represents a helpful reference text for nuclear medicine technologists, nuclear medicine residents and nuclear medicine physicians, and, given its clarity and simplicity, for all those willing to familiarize themselves with the fundamentals of PET imaging." (M. C. Gilardi, European Journal of Nuclear Medicine and Molecular Imaging, Vol. 33 (1), 2006) "This is an up-to-date short manual that reviews the fundamentals of PET imaging. The chapters are sufficiently comprehensive to make the topic easily understandable ... . The text is concise and accompanied by tables, appendixes ... making the book a valuable reference ... . a self-evaluation section is available with a set of short questions that helps the reader to assess the sufficiency of knowledge gained. Residents taking board examinations would particularly benefit ... . Overall, this is an excellent short manual ... ." (A. Manrique, Surgical and Radiologic Anatomy, Vol. 27 (4), 2005) "Dr. Gopal B. Saha has written a clear and concise primer on PET. This text would be excellent for technologists, residents, or physicians who want to become familiar with the basics of PET and would also be an ideal reference for anyone preparing for accreditation examinations. ... Several photographs, diagrams, and tables further each discussion. ... I found this book to be of great value both in content and in price." (Colleen M. Nall, Journal of Nuclear Medicine Technology, Vol. 34 (1), 2006)

Contenuti

Preface Chapter 1Radioactive Decay and Interaction of Radiation with Matter Atomic StructureRadioactive DecayGeneral Radioactive Decay EquationsSuccessive Decay EquationsUnits of RadioactivityUnits of Radioactivity in System InternationaleCalculationInteraction of Radiation with Matter    Interaction of Charged Particles with Matter    Interaction of ( Radiation with Matter    Attenuation of ( RadiationsQuestionsReferences and Suggested Reading Chapter 2PET Scanning Systems     Background    Solid Detectors in PET    Photomultiplier Tube    Pulse Height Analyzer    Arrangement of Detectors    PET Scanners    Hybrid Scintillation Cameras    PET/CT Scanners    Small Animal PET Scanner    Mobile PETQuestionsReferences and Suggested Reading Chapter 3Data Acquisition and Corrections Data Acquisition    Two-dimensional versus three-dimensional    PET/CT data acquisitionFactors Affecting Acquired Data    Normalization    Photon Attenuation    Random Coincidences    Scatter Coincidences    Dead Time    Radial ElongationQuestionsSuggested Reading Chapter 4Image Reconstruction, Storage and Display Simple BackprojectionFiltered Backprojection    The Convolution Method    The Fourier Method    Types of FiltersIterative Reconstruction3-D ReconstructionPartial Volume EffectStorageDisplaySoftware and DICOMPACSTeleradiologyQuestionsReferences and Suggested Reading Chapter 5Performance Characteristics of PET Scanners Spatial ResolutionSensitivityNoiseScatter FractionContrastQuality Control of PET Scanners    Daily Quality Control Tests    Weekly Quality Control TestsAcceptance Tests    Spatial Resolution    Sensitivity    Scatter Fraction    Count Rate Losses and Random CoincidencesQuestionsReferences and Suggested Reading Chapter 6Cyclotron and Production of PET Radionuclides Cyclotron OperationTarget and its ProcessingEquation for Production of RadionuclidesSpecific ActivityProduction of Short-lived Positron-emitters    Fluorine-18    Carbon-11    Nitrogen-13    Oxygen-15    Iodine-124    Strontium-82    Technetium-94mQuestionsSuggested Reading Chapter 7Synthesis of PET Radiopharmaceuticals PET Radiopharmaceuticals    18F-Sodium Fluoride    18F-Fluorodeoxyglucose (FDG)    6-18F-L-Fluorodopa    18F-Fluorothymidine (FLT)    15O-Water    n-15O-Butanol    13N-Ammonia    11C-Sodium Acetate    11C-Flumazenil    11C-Methylspiperone (MSP)    11C-L-Methonine    11C-Raclopride    82Rb-Rubidium ChlorideAutomated Synthesis DevicesQuality Control of PET RadiopharmaceuticalsSpecifications for Routine PET Radiopharmaceuticals    18F-FDG    6-18F-L-Fluorodopa    13N-AmmoniaQuestionsReferences and Suggested Reading Chapter 8Regulations Governing PET Radiopharmaceuticals Food and Drug Administration    Radioactive Drug Research CommitteeRadiation Regulations for PET Radiopharmaceuticals    License or Registration    Regulations for Radiation ProtectionPrinciples of Radiation Protection    Time    Distance    Shielding    Activity    Do’s and Don’ts in Radiation Protection PracticeDepartment of TransportationDistribution of 18F-FDGQuestionsReferences and Suggested Reading Chapter 9Reimbursement for PET Procedures BackgroundCoverageCoding    CPT, HCPCS and APC Codes    ICD-9-CM CodesPayment    Hospital Inpatient Services – Medicare    Hospital Outpatient Services – Medicare    Freestanding Imaging Center – Medicare    Non-Medicare Payers – all settingsBilling    Billing ProcessChronology of PET ReimbursementQuestionsReferences and Suggested Reading Chapter 10Design and Cost of PET Center Site PlanningPassagePET Center    PET Scanner Section    Cyclotron Section    Office AreaCaveatShielding    Case StudyCost of PET OperationQuestionsReferences and Suggest Reading Chapter 11Procedures for PET Studies Whole Body PET Imaging with 18F-FDGWhole Body PET/CT imaging with 18F-FDGMyocardial Perfusion Imaging with 82RbMyocardial Metabolic Imaging with 18F-FDGAddendum    82Rb Infusion Pump Appendix A.Abbreviations Used in the TextAppendix B.Terms Used in the TextAppendix C.Units and ConstantsAppendix D.Estimated Absorbed Doses From Intravenous Administration of 18F-FDG and 82Rb-RbClAppendix E.Evaluation of Tumor Uptake of 18F-FDG by PETAppendix F.Answers to Questions Index

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