Multistate GTPase Control Co-translational Protein Targeting: Doctoral Thesis for Chemistry Accepted by California Institute of Technology, Pasadena, Ca, USA - Rilegato

Zhang, Xin

Rilegato

ISBN 10: 1441978070 ISBN 13: 9781441978073

Casa editrice: Springer Nature, 2011

Riassunto

Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes. This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.

Written while completing graduate work at California Institute of Technology.

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Informazioni sull?autore

Xin Zhang, PhD, received his Doctorate from The California Institute of Technology and now works at The Scripps Research Institute

Dalla quarta di copertina

Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery function and will eventually lead to a novel understanding of various biological processes.

This dissertation comprehensively demonstrates how two universally conserved guanosine triphosphatases in the signal recognition particle and its membrane receptor maintain the efficiency and fidelity of the co-translational protein targeting process essential to all cells. A series of quantitative experiments reveal that the highly ordered and coordinated conformational states of the machinery are the key to their regulatory function. This dissertation also offers a mechanistic view of another fascinating system in which multistate protein machinery closely control critical biological processes.

Dettagli dell?edizione

• Editore: Springer Nature
• Data di pubblicazione: 2011
• Lingua: Inglese
• ISBN 10: 1441978070
• ISBN 13: 9781441978073
• Rilegatura: Copertina rigida
• Numero di pagine: 96
• Contatto del produttore: non disponibile
• Persona responsabile: CMN Printpool Inh. Mathis Neumann; https://www.also.com/ec/cms5/en_6000/6000/index.jsp; ; Friedrich-Karl-Str. 9; Hamburg; Germania