I. Chemical Background of Endocrine Function.- 1. Structure of Protein and Peptide Hormones.- I. Introduction.- II. Peptide Hormones.- A. Posterior Pituitary.- B. Hypothalamus.- C. Anterior Pituitary.- D. Pancreas.- E. Blood.- III. Protein Hormones.- A. Anterior Pituitary and Placenta.- IV. Iodoproteins.- V. Catecholamines and Indoleamines.- References.- 2. Histology of the Pituitary.- I. Introduction.- II. Posterior Pituitary.- III. Anterior Pituitary.- References.- 3. Essentials of Steroid Structure, Nomenclature, Reactions, Biosynthesis, and Measurements.- I. Introduction.- II. Basic Steroid Structure and Nomenclature.- A. Cyclohexane and Stereochemistry.- B. The Steroid Nucleus.- C. Essentials of Steroid Nomenclature.- III. Functional Groups in Steroids and Their Chemical Reactions.- A. Simple Functional Groups.- B. Complex Functional Groups.- C. Steroid Sulfates and Glucuronides.- IV. Enzymes and Steroid Transformations.- A. Hydroxylases.- B. Dehydrogenases.- C. Lyases.- D. Conjugation and Deconjugation Enzymes.- E. Miscellaneous Enzymes.- V. Biosynthesis of Steroids.- A. Biosynthesis of Pregnenolone.- B. Biosynthesis of Progestins.- C. Biosynthesis of Androgens.- D. Biosynthesis of Estrogens.- VI. Selected Methods of Steroid Measurement.- A. Double Isotope Derivatives.- B. Gas-Liquid Chromatography.- C. Saturation Analysis.- VII. Summary.- References.- 4. Neurotransmitter Systems: Anatomy and Pharmacology.- I. Introduction.- II. Methodology of Psychopharmacology.- A. Mode of Action of Neuropharmacological Agents.- B. Psychopharmacological Techniques.- III. Neuroanatomy of Cholinergic and Monoaminergic Pathways.- A. The Norepinephrine Systems.- B. The Epinephrine System.- C. The Dopamine Systems.- D. The Serotonin Systems.- E. The Acetylcholine Systems.- F. The Peptidergic Systems.- References.- II. Development of Reproductive Function.- 5. Hormonal Actions on the Sexual Differentiation of the Genitalia and the Gonadotropin-Regulating Systems.- I. Brief History of the Problem.- II. Normal Embryogenesis of the Genital System.- A. Sex Determination and Differentiation of the Gonads ..- B. Differentiation of the Genital Ducts.- C. Differentiation of the Urogenital Sinus and Genital Tubercle.- D. Differentiation of the Mammary Glands.- III. The Effects of Exogenous Estrogens on Embryogenesis of the Genital System.- IV. Disturbances in Embryogenesis of the Genital System.- A. Disturbances of the Sex Determination Process.- B. Disturbances of Gonadal Differentiation.- C. Disturbances of Androgen Action.- D. Disturbances of Müllerian Duct Inhibitor Action.- V. Differentiation of Gonadotropin Release Systems.- A. Age Factors in Differentiation of Gonadotropin Release Patterns.- B. Steroidal Factors in Differentiation of Gonadotropin Release Patterns.- C. Site of Action of Hormones Involved in Differentiation of Gonadotropin Release Patterns.- D. Mechanisms for the Protection of Female Fetuses from Masculinizing Agents.- VI. Summary.- References.- 6. Perinatal Hormones and Their Role in the Development of Sexually Dimorphic Behaviors.- I. Brief History of the Problem.- II. Prenatal Hormones and Their Effects on the Sex Behavior ofAdult Guinea Pigs.- III. Eight Questions Regarding "Organizing" Effects of Hormones.- A. Are There "Organizing" and "Activating" Effects of Hormones? A Matter of Terminology.- B. Are There Critical Periods or Periods of Maximal Susceptibility to Perinatal Hormones?.- C. Are There Parallels between Genital Differentiation and Neural Organization?.- D. Organizational Effects-Structural or Functional?.- E. Perinatal Hormones-Are Their Effects on the Nervous System General or Localized?.- F. What Is the Effective Perinatal Hormone-Is It Testosterone or a Metabolite of Testosterone?.- G. Do Perinatal Hormones Influence Noncopulatory as Well as Copulatory Behavior?.- H. Do Prenatal Hormones Influence Behavior of Primates?.- IV. Summary.- References.- 7. Early Organizational Effects of Hormones: An Evolutionary
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