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This book discusses the connection between obesity and breast cancer in older women. It explores the application of novel therapies to inhibit aromatase in the breast.
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Kristy A. Brown, Ph.D., is a NHMRC Career Development Fellow and Co-Head of the Metabolism and Cancer Group at Prince Henry's Institute. Dr. Brown is also an Adjunct Lecturer of Physiology at Monash University. Dr Brown's area of research interest is the regulation of the aromatase gene in the context of obesity and breast cancer.
Evan Simpson, Ph.D., is a Senior Principal Research Fellow and Co-Head of the Metabolism and Cancer group at Prince Henry's Institute. He is also an Honorary Professor for the Department of Biochemistry and Molecular Biology and Monash University. Dr. Simpson is the Laboratory Director of the Victorian Breast Cancer Research Consortium. This consortium involves eight medical research institutes and was established in 1997 to conduct world class research into breast cancer. Dr. Simpson's work also led to the creation of the first aromatase knockout (ArKO) mouse, which is a model of oestrogen insufficiency that compares with the phenotype of humans with natural mutations in aromatase. His current research is focused on the role of oestrogen in several important health conditions, including obesity, diabetes, osteoporosis and of course, breast cancer.
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Obesity and Breast Cancer
Editore:
Springer New York, 2013
ISBN 10: 1489980016
ISBN 13: 9781489980014
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Obesity and Breast Cancer
Editore:
Springer New York Nov 2013, 2013
ISBN 10: 1489980016
ISBN 13: 9781489980014
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research. 68 pp. Englisch. Codice articolo 9781489980014
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Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism (Paperback or Softback)
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ISBN 13: 9781489980014
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Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism (SpringerBriefs in Cancer Research)
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Obesity and Breast Cancer
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Springer New York, Springer US Nov 2013, 2013
ISBN 10: 1489980016
ISBN 13: 9781489980014
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Taschenbuch. Condizione: Neu. Neuware -Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters.Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer.Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast.This SpringerBrief will explore all of these issues in depth and the authorsare in a unique position to write about this topic,havingextensive experience in the field of aromatase research.¿Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 68 pp. Englisch. Codice articolo 9781489980014
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Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism (SpringerBriefs in Cancer Research)
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Obesity and Breast Cancer : The Role of Dysregulated Estrogen Metabolism
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Obesity and Breast Cancer : The Role of Dysregulated Estrogen Metabolism
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ISBN 10: 1489980016
ISBN 13: 9781489980014
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Taschenbuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research. Codice articolo 9781489980014
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Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism (SpringerBriefs in Cancer Research)
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Obesity and Breast Cancer: The Role of Dysregulated Estrogen Metabolism
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ISBN 10: 1489980016
ISBN 13: 9781489980014
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Paperback / softback. Condizione: New. This item is printed on demand. New copy - Usually dispatched within 5-9 working days 144. Codice articolo C9781489980014
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