Practical Process Research and Development - A guide for Organic Chemists [Lingua inglese] - Brossura

Anderson, Neal G.

Brossura

ISBN 10: 149330125X ISBN 13: 9781493301256

Casa editrice: Academic Press, 2016

Riassunto

Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry" Second Edition highlights: Reflects the current thinking in chemical process R&D for small molecules. Retains similar structure and orientation to the first edition. Contains approx. 85% new material. Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) Replaces theÿfirst edition, although the first edition contains useful older examples that readers may refer to

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Informazioni sull?autore

Neal G. Anderson is a synthetic organic chemist with over 40 years of experience in chemical process R&D in the pharmaceutical industry. He earned a B.S. degree in biology from the University of Illinois and a Ph.D. in medicinal chemistry from the University of Michigan, followed by industrial post-doctoral studies at McNeil Laboratories. He has extensive hands-on experience in the laboratory, pilot plant, and in manufacturing facilities. At Squibb / Bristol-Myers Squibb he made key contributions to processes for the manufacture of four major drug substances, including captopril, and has participated in 12 manufacturing start-ups and introductions of many processes to pilot plants. He received a BMS President's Award and spot awards, and his final position was Principal Scientist. In 1997, Anderson established Anderson’s Process Solutions L.L.C., a consulting firm based in the USA to offer practical guidance on developing and implementing processes for bulk pharmaceuticals and fine chemicals. As part of these consulting services, he presents courses on selected aspects of practical process R&D. He is experienced in laboratory research, scale-up, and technology transfer to ensure reproducibility and optimal product quality.

Dettagli dell?edizione

• Editore: Academic Press
• Data di pubblicazione: 2016
• Lingua: Inglese
• ISBN 10: 149330125X
• ISBN 13: 9781493301256
• Rilegatura: Copertina flessibile
• Numero edizione: 2
• Numero di pagine: 488
• Contatto del produttore: non disponibile