A state-of-the-art examination of research in this field and the impact of this gram-positive pathogen on human disease. • Provides coverage of topics in basic microbiology such as details of DNA transformation, molecular and medical epidemiology, the molecular basis of invasive disease, and various interactions with host defenses. • Presents important historical information on the field of pneumococcal research and suggests strategies for future investigation. • Serves as a valuable source of information for graduate and medical school students, infectious disease specialists, and field researchers in the pathogenesis of gram-positive bacteria.
This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.
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Table of Contents The Bacteria 1. What is a Pneumococcus? Christopher G. Dowson 2. Comparative Genomics of S. pneumoniae: Intra-Strain Diversity and Genome Plasticity, Hervé Tettelin and Susan Hollingshead 3. Capsule, Janet Yother 4. Choline-Binding Proteins, Edwin Swiatlo, Larry S. McDaniel, and David E. Briles 5. Pneumolysin and Other Virulence Proteins, Tim J. Mitchell 6. Cell Wall Hydrolases, Rubens Lopez, Ernesto Garcia, Pedro Garcia, and José Luis Garcia 7. Transformation, Sanford A. Lacks Host-Microbe Interactions 8. Evolutionary and Population Biology of Streptococcus pneumoniae, Brian G. Spratt, William P. Hanage, and Angela B. Brueggemann 9. Pneumococcal Carriage, Derrick W. Crook, Angela B. Brueggemann, Karen Sleeman, and Timothy E. A. Peto 10. Epidemiology of Pneumococcal Disease, Jay C. Butler 11. Mechanisms of Carriage, Jeffrey N. Weiser Invasion and Infection 12. Inflammation and Host Defense, Paul Anthony Majcherczyk and Philippe Moreillon 13. Interactions of Streptococcus pneumoniae with the Proteins of the Complement Pathways, Margaret K. Hostetter 14. A Pathogenic Categorization of Clinical Syndromes Caused by Streptococcus pneumoniae, Daniel M. Musher 15. Attachment and Invasion of the Respiratory Tract, Elaine I. Tuomanen 16. Pathogenesis of Pneumococcal Meningitis, Joerg R. Weber 17. Immunodeficiency and Invasive Pneumococcal Disease, Edward N. Janoff and Jeffrey B. Rubins Treatment and Prevention 18. Changing the Ecology of Pneumococci with Antibiotics and Vaccines, Ron Dagan and Marc Lipsitch 19. Pneumococcal Infections: Therapeutic Strategies and Pitfalls, Kathryn M. Edwards 20. Clinical Relevance of Antibiotic Resistance in Pneumococcal Infections, Keith P. Klugman 21. Mechanisms for Penicillin Resistance in Streptococcus pneumoniae: Penicillin Binding Proteins, Gene Transfer, and Cell Wall Metabolism, Carina Bergmann, Fang Chi, Shwan Rachid and Regine Hakenbeck 22. Macrolide, Quinolone, and Other Non-ß-Lactam Antibiotic Resistance in Streptococcus pneumoniae, Karita Ambrose and David S. Stephens 23. The Humoral Immune Response to Streptococcus pneumoniae, Clifford M. Snapper, Jesus Colino, Abdul Q. Khan and Zheng Qi Wu 24. New Pneumococcal Vaccines: Basic Science Developments, James C. Paton 25. Vaccine-Induced Immunity, H. Käyhty and H. Mäkelä
particularly fascinating topics covered in this volume include: comparative gram positive genomics; human and bacterial determinants of colonization versus invasive disease; gram positive interaction with innate immune response; traffic of bacteria through epithelia and endothelia; continuing evolution of antibiotic resistance; building the ultimate vaccine.
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