This is the proceedings volume of a NATO Advance Study Institute held in Erice, Italy, in July 2003, bringing together experts applying various physical methods to problems of macro molecular dynamics, including x-ray diffraction, NMR and other forms of spectroscopy, and macromolecular dynamics measurements and simulations. Eleven contributions cover a range of topics representing the critical problems in biology. A sampling of topics: ultrafast kinetic studies and the protein folding "speed limit," thermodynamic and kinetic aspects of protein folding, NRM studies of protein complexes, Bayesian restrain potentials for consistent inference of biomolecular structure from NRM data, novel insights into the mechanism of retinol binding by cellular retinol- binding protein, molecular dynamics simulations, and x-ray structure and function study of the ribosome. No subject index. Annotation ©2006 Book News, Inc., Portland, OR (booknews.com)
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This publication brings together the work of experts applying different physical methods to problems of macromolecular dynamics - notably x-ray diffraction, NMR and other forms of spectroscopy, and macromolecular dynamics measurements and simulations. Emphasis was placed on correlating structural problems with mechanisms of biological function. The range of topics in this book represent the diversity of critical problems in biology, from protein structure determination and folding dynamics to the mechanisms of allostery in enzymes from RNA structure and function in viral disease to the triumph of the ribosome structure. The individual articles represent the state-of-the-art in each area covered and provide a guide to the original literature in this rapidly developing field.
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