FGF Signalling in Vertebrate Development - Brossura

Mary Elizabeth Pownall (author) & Harry Isaacs (author)

Brossura

ISBN 10: 1615040633 ISBN 13: 9781615040636

Casa editrice: Morgan & Claypool, 2010

Riassunto

The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right-left asymmetry. Table of Contents: Introduction / FGF Ligands / FGF Receptors / Heparan Sulphate Proteoglycans / FGF Signal Transduction / Regulators / Integration with Other Signalling Pathways / Mesoderm Induction / Neural Induction / FGF Signalling and Posterior Neural Patterning / FGF Signalling at the Isthmic Organizer / FGF Signalling at the Anterior Neural Ridge / Morphogenesis / Somitogenesis / FGF and Myogenesis / Limb Development / FGF and Left-Right Asymmetry / Perspectives / References / About the Authors

Dettagli dell'edizione

• Editore: Morgan & Claypool
• Data di pubblicazione: 2010
• Lingua: Inglese
• ISBN 10: 1615040633
• ISBN 13: 9781615040636
• Rilegatura: Copertina flessibile
• Numero di pagine: 75
• Contatto del produttore: non disponibile
• Persona responsabile: gpsr@libri.de; gpsr@libri.de; ; Europaallee 1; Bad Hersfeld; 36244; Germania