Proprotein Convertases: Discovery, Characteristics, and Link to Tumor Progression and Metastasis - Brossura

Khatib, Abdel-Majid

Brossura

ISBN 10: 1615045368 ISBN 13: 9781615045365

Casa editrice: Morgan & Claypool Life Sciences, 2013

Riassunto

Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. These enzymes are involved in the maturation of many precursor proteins involved in the process of tumorigenesis and metastasis. Since their discovery, PCs were suggested as potential targets for anti-cancer therapy, and their activity was found to directly affect tumor cell proliferation, migration invasion, and the malignant phenotypes of tumor cells. Here, we discuss a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells, and their clinical relevance in cancer patients. Among the substrates of the proprotein convertases, various growth factors, their receptors, adhesion molecules, and proteases were identified. The PCs are inhibited by endogenous and exogenous inhibitors. To date, only pro7B2, a specific chaperone of PC2, and the granine-like precursor of neuroendocrine protein proSAAS, a selective ligand of PC1, have been identified as endogenous inhibitors of the PCs found in the regulated pathway. However, only PCs prosegments, several bioengineered inhibitors, peptides, and non-peptide compounds were found to inhibit the activity of the PCs found in the secretory pathway. Table of Contents: Abbreviations / Discovery of Proprotein Convertases / Substrates of the Proprotein Convertases / Inhibitors of the Proprotein Convertases / Proprotein Convertases in Physiology and Pathology / Proprotein Convertases and Tumorigenesis / Acknowledgments / References / Author Biography / Titles of Related Interest

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Product Description

Book by Khatib AbdelMajid

Dettagli dell'edizione

• Editore: Morgan & Claypool Life Sciences
• Data di pubblicazione: 2013
• Lingua: Inglese
• ISBN 10: 1615045368
• ISBN 13: 9781615045365
• Rilegatura: Copertina flessibile
• Numero di pagine: 84
• Contatto del produttore: non disponibile
• Persona responsabile: non disponibile