Drug Discovery for Psychiatric Disorders: Volume 28 - Rilegato

Rilegato

ISBN 10: 1849733651 ISBN 13: 9781849733656

Casa editrice: Royal Society of Chemistry, 2012

Riassunto

1.An authorative reference on the background and advances in psychiatric drug discovery
2.Current treatments often have unpleasant side effects, there is a need to develop more effective treatments
3.Medicinal chemists, pharmacologists, biochemists, those working in psychiatric drug development
4.MedChemComm, Issues in Toxicology Series
5.Covers the evolution, major advances, challenges and future directions in drug discovery and medicinal chemistry for major psychiatric disorders The discovery and development of effective medicines for the treatment of psychiatric disorders is one of the great medical achievements of the past century. This unique book gives in-depth coverage of the field and provides the first point of call for those involved or interested in this rapidly expanding and increasingly fragmented field of research and drug discovery. The editors combine their wide ranging experience and extensive network of contacts with leading scientists and opinion leaders from both academia and industry to provide an authoritative reference text covering the evolution, major advances, challenges and future directions in drug discovery and medicinal chemistry for major psychiatric disorders, such as schizophrenia, depression, anxiety, ADHD, bipolar disorder, addiction and autism. The discovery and development of effective medicines for the treatment of psychiatric disorders such as schizophrenia and depression has been heralded as one of the great medical achievements of the past century. Indeed, the profound impact of these medicines on our understanding of the pathophysiology underlying these diseases, the treatment of psychiatric patients and even our social perception of mental illnesses cannot be underestimated. However, there is still an urgent medical need for even more effective, safe and well-tolerated treatments. For example, currently available treatments for schizophrenia address mainly the positive symptoms and largely neglect the negative symptoms and cognitive disfunction which greatly impact overall morbidity. Similarly, whilst the current first line antidepressants show significantly improved side effect profiles compared to the first generation therapies, there still up to 40% of patients who are treatment resistant, and even in the patient population which responds well, the onset of action is slow at typically 2-3 weeks. The aim of this book is to provide the first point of call for those involved or just interested in this rapidly expanding and increasingly fragmented field of research and drug discovery. The editors will combine their wide ranging experience and extensive network of contacts with leading scientists and opinion leaders in this field to provide an authoritative reference text covering the evolution, major advances, challenges and future directions in drug discovery and medicinal chemistry for major psychiatric disorders.

Su questo libro

Informazioni sull'autore

Zoran Rankovic is a Senior Research Fellow and a Head of Medicinal Chemistry section at MSD, Merck Research Laboratories, U.K. 15 years experience in drug discovery with a track record of delivering compounds into the development for a number of therapeutic areas, including psychiatry. Over a decade of a direct involvement in shaping the early discovery portfolio for the neuroscience franchise. Zoran has a PhD in organic chemistry from the University of Leeds, UK. Richard Hargreaves is Vice President and Worldwide Head of Neuroscience Discovery Research at Merck - completed his doctorate through the Physiology Department at King's College London University UK. Joined Merck's Neuroscience Research Center in Harlow UK in 1988. Leader of the discovery biology teams that contributed to the development of MAXALT(R) (rizatriptan) for the treatment of migraine and EMEND(R) (aprepitant) and IVEMEND(R) (fosaprepitant), novel agents that advance the protective pharmacotherapy of acute and delayed chemotherapy-induced nausea and vomiting and post-operative nausea and vomiting. In 1999 he became Vice President Worldwide Head of Imaging with the assignment to establish and lead a worldwide imaging research strategy for Merck Research Laboratories. Matilda Bingham is currently Team Leader in the Medicinal Chemistry Department, MSD; 8 years research experience in neuroscience research in a pharmaceutical setting, participating and leading teams in the neuroscience area, specialising in the transporter and GPCR target classes.

Dalla quarta di copertina

The discovery and development of effective medicines for the treatment of psychiatric disorders such as schizophrenia and depression has been heralded as one of the great medical achievements of the past century. Indeed, the profound impact of these medicines on our understanding of the pathophysiology underlying these diseases, the treatment of psychiatric patients and even our social perception of mental illnesses cannot be underestimated. However, there is still an urgent medical need for even more effective, safe and well-tolerated treatments. For example, currently available treatments for schizophrenia address mainly the positive symptoms and largely neglect the negative symptoms and cognitive disfunction which greatly impact overall morbidity. Similarly, whilst current first line antidepressants show significantly improved side effect profiles compared to the first generation therapies, there are still up to 40% of patients who are treatment resistant, and even in the patient population which responds well, the onset of action is slow at typically 2-3 weeks. The aim of this book is to provide the first point of call for those involved or just interested in this rapidly expanding and increasingly fragmented field of research in drug discovery. The editors have combined their wide ranging experience and extensive network of contacts with leading scientists and opinion leaders in this field to provide an authoritative reference text covering the evolution, major advances, challenges and future directions in drug discovery for major psychiatric disorders, such as schizophrenia, depression, anxiety, ADHD, bipolar disorder, addiction and autism. Written by leading experts from industry and academia the book will be essential reading for medicinal chemists, pharmacologists, and pharmaceutical scientists working in psychiatric diorders drug discovery and development.

Dettagli dell'edizione

• Editore: Royal Society of Chemistry
• Data di pubblicazione: 2012
• Lingua: Inglese
• ISBN 10: 1849733651
• ISBN 13: 9781849733656
• Rilegatura: Copertina rigida
• Numero di pagine: 590
• Redattore: Rankovic Zoran, Bingham Matilda, Nestler Eric J, Hargreaves Richard
• Contatto del produttore: non disponibile
• Persona responsabile: GPSR Kontakt; gpsr@libri.de; ; Europaallee 1; Bad Hersfeld; 36244; Germania