Apoptosis and Cell Cycle Control in Cancer: Basic Mechanisms and Implications for Treating Malignant Disease - Rilegato

Rilegato

ISBN 10: 1872748899 ISBN 13: 9781872748894

Casa editrice: Garland Science, 1995

Riassunto

Over the past few years, there have been major breakthroughs in our understanding of the molecular mechanisms which control cell division and apoptosis (programmed cell death). This book adopts a multi-disciplinary approach to explore how the deregulation of basic molecular controls can lead to malignancy in a variety of cell types. The authors are leading international experts whose chapters span the state of the art in cell and molecular biology, clinical treatment of cancer and new drug design.

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Contenuti

Introduction to life and death. N.S.B. Thomas, Cell growth and cell cycle progression in mammalian cells. A. Zetterberg, The D-cyclins, their kinases and their inhibitors. G. Peters et al, p53, p21 WAF1/CIP1 and the control of cell proliferation. W.S. El-Deiry, The retinoblastoma family of proteins. P. Whyte, Interactions of HPV E6 and E7 with regulators of cell cycle and proliferation. N.J. Marston and K.H. Vousden, Integrated control of cell proliferation and apoptosis by oncogenes. G.I. Evan et al, Overview: The nature of malignancy. M.J. Cline, Cancer therapy, cell cycle control and death. R. Souhami, In vivo modelling and antisense therapy in malignancy. F.E.Cotter and C.F.E. Pocock, Novel cell cycle targets in cancer. M. Rolfe, Cell proliferation, cell cycle and apoptosis targets for cancer drug discovery: strategies, strengths and pitfalls. P. Workman

Dettagli dell'edizione

• Editore: Garland Science
• Data di pubblicazione: 1995
• Lingua: Inglese
• ISBN 10: 1872748899
• ISBN 13: 9781872748894
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 256
• Redattore: Thomas N.S.B
• Contatto del produttore: non disponibile
• Persona responsabile: non disponibile