G-quadruplex and Microorganisms - Brossura

Brossura

ISBN 10: 3039212435 ISBN 13: 9783039212439

Casa editrice: Mdpi AG, 2019

Riassunto

G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses’ genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms’ genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects.

Dettagli dell'edizione

• Editore: Mdpi AG
• Data di pubblicazione: 2019
• Lingua: Inglese
• ISBN 10: 3039212435
• ISBN 13: 9783039212439
• Rilegatura: Copertina flessibile
• Numero di pagine: 208
• Redattore: Richter Sara N
• Contatto del produttore: non disponibile
• Persona responsabile: non disponibile