B Cell Receptor Signaling - Brossura

Brossura

ISBN 10: 3319798995 ISBN 13: 9783319798998

Casa editrice: Springer, 2018

Riassunto

Thisvolume details our current understanding of the architecture and signalingcapabilities of the B cell antigen receptor (BCR) in health and disease. Thefirst chapters review new insights into the assembly of BCR components andtheir organization on the cell surface. Subsequent contributions focus on themolecular interactions that connect the BCR with major intracellular signalingpathways such as Ca²⁺ mobilization, membrane phospholipidmetabolism, nuclear translocation of NF-kB orthe activation of Bruton’s Tyrosine Kinase and MAP kinases. These elementsorchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamicsfor antigen internalization. Furthermore, a key mechanism of how B cellsremember their cognate antigen is discussed in detail. Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, while also paving the way for eventually combating thesediseases.

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Informazioni sull'autore

Tomohiro Kurosaki, MD, PhD, is a professor at WPI Immunology Frontier Research Center at Osaka University, JapanJürgen Wienands, PhD, is a professor of Cellular and Molecular Immunology at the University of Göttingen, Germany

Dettagli dell'edizione

• Editore: Springer
• Data di pubblicazione: 2018
• Lingua: Inglese
• ISBN 10: 3319798995
• ISBN 13: 9783319798998
• Rilegatura: Copertina flessibile
• Numero di pagine: 244
• Redattore: Kurosaki Tomohiro, Wienands Jürgen
• Contatto del produttore: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3,69115 Heidelberg, Germany; Heidelberg; 69115; Germania