CA19.9 in differentiating benign and malignant obstructive jaundice - Brossura

Azam, Mohammad Golam; Bhuyian, Rokanuzzaman

 
9783330337107: CA19.9 in differentiating benign and malignant obstructive jaundice
Brossura
ISBN 10: 3330337109 ISBN 13: 9783330337107
Casa editrice: LAP LAMBERT Academic Publishing, 2017

Sinossi

Serum carbohydrate antigen 19-9 (CA 19-9), a tumour marker for malignancies of the hepatobiliary tract and pancreas, frequently elevated in a number of non-malignant conditions that are associated with jaundice. The CA 19-9 tends to normalize the following restoration of biliary drainage. Sixty three patients presented with obstructive jaundice on the basis of clinical and imaging methods with elevated CA 19-9 were studied. Diagnostic accuracy of CA19-9 in the detection of malignancy was estimated by the receiver operating characteristic (ROC) curve. Median value of CA 19-9 in malignant cases was higher (1000 U/ml) than benign cases (93 U/ml) (p=0.001). After biliary drainage serum CA19-9 levels normalized in 15(50%) benign and 1(3%) malignant cases (p=0.001). The AUC of CA 19-9 was 0.825. Diagnostic accuracy of CA 19-9 was observed more at cut off value 200 U/ml. Deranged CA19-9 is frequently observed in benign conditions with jaundice and shown to normalize following improvement of biliary drainage. Caution is necessary in the interpretation of an elevated serum CA 19-9 value as a marker for malignancy, especially in patients with benign cholestasis.

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Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2017
Lingua
Inglese
ISBN 10 
3330337109
ISBN 13 
9783330337107
Rilegatura
Copertina flessibile
Numero di pagine
60
Contatto del produttore
non disponibile
Persona responsabile
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