Structure-Based Drug Design: Thermodynamics, Modeling and Strategy - Rilegato

Ladbury, John E.

Rilegato

ISBN 10: 3540632506 ISBN 13: 9783540632504

Casa editrice: R G Landes Co, 1997

Riassunto

This book connects two subjects: "drug design" - a biological science - and "thermodynamics" - a physical science. Armed with the knowledge of the three-dimensional structure of a potential binding site of a molecule, the method of structure-based design provides a rapid, rational route to a ligand molecule. Recent developments in the determination of structure and the measurement of thermodynamic parameters of binding have resulted in drawing theoretical and experimental data together to improve our ability to model these interactions de novo. This book presents the state of the art and outlines future developments in the field of structure-based ligand design.

Su questo libro

Contenuti

Applications of free energy calculations to drug design.- Energetic dissection of specificity in serine proteases.- Model compounds and interpretation of protein-ligand interactions.- A structure-based thermodynamic approach to molecular design.- The cost of release site-specific, bound water molecules from proteins: toward a quantitative guide for structure-based drug design.- Exploring unchartered waters: water molecules in drug design strategies.

Dettagli dell'edizione

• Editore: R G Landes Co
• Data di pubblicazione: 1997
• Lingua: Inglese
• ISBN 10: 3540632506
• ISBN 13: 9783540632504
• Rilegatura: Copertina rigida
• Numero edizione: 1
• Numero di pagine: 187
• Contatto del produttore: non disponibile
• Persona responsabile: non disponibile