Medical Applications of Finite Mixture Models - Rilegato

Libro 31 di 69: Statistics for Biology and Health

Schlattmann, Peter

 
9783540686507: Medical Applications of Finite Mixture Models
Rilegato
ISBN 10: 3540686509 ISBN 13: 9783540686507
Casa editrice: Springer Verlag, 2009

Sinossi

Patients are not alike! This simple truth is often ignored in the analysis of me- cal data, since most of the time results are presented for the average patient. As a result, potential variability between patients is ignored when presenting, e.g., the results of a multiple linear regression model. In medicine there are more and more attempts to individualize therapy; thus, from the author s point of view biostatis- cians should support these efforts. Therefore, one of the tasks of the statistician is to identify heterogeneity of patients and, if possible, to explain part of it with known explanatory covariates. Finite mixture models may be used to aid this purpose. This book tries to show that there are a large range of applications. They include the analysis of gene - pression data, pharmacokinetics, toxicology, and the determinants of beta-carotene plasma levels. Other examples include disease clustering, data from psychophysi- ogy, and meta-analysis of published studies. The book is intended as a resource for those interested in applying these methods.

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

Dalla quarta di copertina

The book shows how to model heterogeneity in medical research with covariate adjusted finite mixture models. The areas of application include epidemiology, gene expression data, disease mapping, meta-analysis, neurophysiology and pharmacology.

After an informal introduction the book provides and summarizes the mathematical background necessary to understand the algorithms.

The emphasis of the book is on a variety of medical applications such as gene expression data, meta-analysis and population pharmacokinetics. These applications are discussed in detail using real data from the medical literature.

The book offers an R package which enables the reader to use the methods for his/her needs.

Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

Editore
Springer Verlag
Data di pubblicazione
2009
Lingua
Inglese
ISBN 10 
3540686509
ISBN 13 
9783540686507
Rilegatura
Copertina rigida
Numero edizione
1
Numero di pagine
246
Contatto del produttore
non disponibile
Persona responsabile
ProductSafety@springernature.com
ProductSafety@springernature.com

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Altre edizioni note dello stesso titolo

9783642088162: Medical Applications of Finite Mixture Models

Edizione in evidenza

ISBN 10:  3642088163 ISBN 13:  9783642088162
Casa editrice: Springer, 2010
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