The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. In this book, well known experts present their most recent findings on the fast developing kinase field. It will be of interest to basic researchers and the pharmaceutical industry.
Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.
Proteomics-Based Strategies in Kinase Drug Discovery.- PKC Isotype Functions in T Lymphocytes.- Migration, Cell–Cell Interaction and Adhesion in the Immune System.- Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts.- Fragment-Based Drug Discovery Using Rational Design.- Systems Biology of T Cell Activation.- Solving the IRAK-4 Enigma: Application of Kinase-Dead Knock-In Mice.- Sensing, Presenting, and Regulating PAMPS.- The Role of Diacylglycerol Kinases in T Cell Anergy.
Sparking Signals: Kinases As Molecular Signaltransducers And Pharmacologial Drug Targets In Inflammation BY Baier, G., Schraven, B., Zügel, U., Springer, Hardcover, 2008
Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.
Da: Research Ink, Takoma Park, MD, U.S.A.
Hardback. Condizione: Very Good. xiv + 187 pp. Ernst Schering Foundation Symposium Proceedings, 2007/3. Rubber-stamped on front free endpaper. book. Codice articolo 36721
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Da: Research Ink, Takoma Park, MD, U.S.A.
Hardback. Condizione: Very good. 187 pp. Ernst Schering Foundation Symposium Proceedings. Rubber-stamped on front free endpaper. book. Codice articolo 32353
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Da: Antiquariat Kretzer, Kirchhain-Emsdorf, Germania
Condizione: Wie neu. XIV, 185 Seiten. Mit 34 Abbildungen. Neuwertiges Exemplar. / As new. ISBN: 9783540735007 Sprache: Englisch Gewicht in Gramm: 990 8° (17,5-22,5 cm). Orig.-Pappband. [Hardcover / fest gebunden]. Codice articolo 3088058
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Da: Basi6 International, Irving, TX, U.S.A.
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Da: Buchpark, Trebbin, Germania
Condizione: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | Protein phosphorylation is an essential post-translational modification that modulates cell¿cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups. Codice articolo 4160433/12
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