Algorithmic Study on Mass Spectrometry and Proteomics: Methods for Proteomic Mass Spectrometry Data Analysis - Brossura

Lu, Bingwen

Brossura

ISBN 10: 3639033078 ISBN 13: 9783639033076

Casa editrice: Vdm Verlag Dr Mueller E K, 2008

Riassunto

Tandem mass spectrometry has emerged to be one of the most powerful techniques for proteomics study. We aimed to improve existing algorithms and develop new algorithms for proteomic mass spectrometry data analysis. Three studies were presented in this book. (1) De novo peptide sequencing via tandem mass spectrometry is of interest in various situations. We developed a dynamic-programming-based suboptimal algorithm for de novo peptide sequencing. (2) A major known problem for protein and peptide identification using mass spectrometry database search is that the speed of database search is too slow, especially when searching against a large sequence database. To cope with this situation, we designed speedup algorithms for the searching process. We employed an approach combining suffix tree data structure and spectrum graph. (3) The biological inference from proteomics data generated by mass spectrometers is a challenging problem. In this study, we first introduce some difficult issues in proteomics data analysis and then we show how we managed and visualized proteomics data by using both in-house and publicly available software tools.

Dettagli dell'edizione

• Editore: Vdm Verlag Dr Mueller E K
• Data di pubblicazione: 2008
• Lingua: Inglese
• ISBN 10: 3639033078
• ISBN 13: 9783639033076
• Rilegatura: Copertina flessibile
• Numero di pagine: 100
• Contatto del produttore: non disponibile
• Persona responsabile: non disponibile