Articoli correlati a Engineering of Halogenases towards Synthetic Applications:...

Engineering of Halogenases towards Synthetic Applications: Increasing the Thermostability and Investigations on a Marine Brominase Bmp5 - Brossura

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Minges, Hannah

 
9783658184094: Engineering of Halogenases towards Synthetic Applications: Increasing the Thermostability and Investigations on a Marine Brominase Bmp5
Brossura
ISBN 10: 3658184094 ISBN 13: 9783658184094
Casa editrice: Springer Spektrum, 2017

Sinossi

Hannah Minges focuses on the investigation of two different FAD-dependent halogenases in order to analyze and improve their applicability for chemoenzymatic approaches in chemistry. Owing to beneficial features, like high selectivity and benign reaction conditions, nature’s toolkit for halogenation provides several advantages, whereas conventional chemical strategies require hazardous reagents and suffer from low selectivity. Therefore, enzymatic halogenation arises as promising alternative in the synthesis of valuable chemicals. One project focuses on the generation of a thermostable variant of the tryptophan halogenase Thal by means of directed evolution. The second project deals with the investigation of the marine halogenase Bmp5. This enzyme is of synthetic interest because it preferably introduces bromine into phenol compounds, whereas chlorination cannot take place. 

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

Informazioni sull'autore

Hannah Minges, a Ph.D student at Bielefeld University, works on the optimization of tryptophan halogenases by means of directed evolution.

Dalla quarta di copertina

Hannah Minges focuses on the investigation of two different FAD-dependent halogenases in order to analyze and improve their applicability for chemoenzymatic approaches in chemistry. Owing to beneficial features, like high selectivity and benign reaction conditions, nature’s toolkit for halogenation provides several advantages, whereas conventional chemical strategies require hazardous reagents and suffer from low selectivity. Therefore, enzymatic halogenation arises as promising alternative in the synthesis of valuable chemicals. One project focuses on the generation of a thermostable variant of the tryptophan halogenase Thal by means of directed evolution. The second project deals with the investigation of the marine halogenase Bmp5. This enzyme is of synthetic interest because it preferably introduces bromine into phenol compounds, whereas chlorination cannot take place. 


Contents
  • Halogenating Enzymes
  • Identification of a Thermostable Thal Variant by Directed Evolution
  • Establishment of the Brominase Bmp5 for Synthetic Application 
Target Groups
Lecturers, students and researchers in biological chemistry and chemistry

The Author
Hannah Minges, a Ph.D student at Bielefeld University, works on the optimization of tryptophan halogenases by means of directed evolution.

Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

Editore
Springer Spektrum
Data di pubblicazione
2017
Lingua
Inglese
ISBN 10 
3658184094
ISBN 13 
9783658184094
Rilegatura
Copertina flessibile
Numero edizione
1
Numero di pagine
128
Contatto del produttore
non disponibile
Persona responsabile
GPSR Kontakt
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