Modelling Proteasome Dynamics in a Bayesian Framework - Brossura

Stübler, Sabine

Brossura

ISBN 10: 3658201665 ISBN 13: 9783658201661

Casa editrice: Springer Spektrum, 2017

Riassunto

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.

Su questo libro

Informazioni sull'autore

Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

Dalla quarta di copertina

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.

Contents

• Structure and Function of the Proteasome
  
• Approaches to Model Proteasome Dynamics
  
• Comparison of the Dynamics of Proteasome Subtypes
  
• Inhibitor Influence on the Catalytic Subunits 
  
• Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model 

Target Groups

• Lecturers and students of systems biology, immunology and cell biology
  
• Practitioners from the fields of systems biology, immunology and cell biology

About the Author

Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

Dettagli dell'edizione

• Editore: Springer Spektrum
• Data di pubblicazione: 2017
• Lingua: Inglese
• ISBN 10: 3658201665
• ISBN 13: 9783658201661
• Rilegatura: Copertina flessibile
• Numero edizione: 1
• Numero di pagine: 112
• Contatto del produttore: non disponibile
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