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Formulation and Optimization of Solid Dispersions by BoxBehnken Design: Box-behnken Design - An effective tool in Solid Dispersion - Brossura
Sinossi
The objective of this study was to prepare and evaluate solid dispersion of poorly water soluble drug Telmisartan, a candidate mainly from the class II category of BCS classification, to increase solubility and for enhancement of bioavailability. The solid dispersions were prepared by physical mixture method using PEG 6000, Eudrajit L 100 and PVP K 30 as a carrier. A Box Behnken design has been applied to study the effect of independent variables i.e. PEG 6000, Eudrajit L 100 and PVP K 30 on dependent variables i.e. % Cumulative Drug Release and time required for cumulative drug release . Response surface plots and counter plots were drawn and optimum formulations were selected based on feasibility search method. Validation of optimized study performed using three confirmatory runs indicated very high degree of prognostic ability of response surface methodology, with mean percentage error as +0.02. Optimized solid dispersion formulations were prepared and its effect on % Cumulative Drug Release and time was evaluated. Optimized solid dispersions were evaluated for % CDR and Time for CDR, FTIR, DSC, SEM and in vitro drug release study.
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L'autore
Mr. Niranjan Chivate has completed Master’s degree in Pharmacy(P'ceutics)in year 2012. He has industrial and marketing experience of eight years. Presently working as a Lecturer and Co-ordinator at KCT’s Krishna College of Pharmacy, Karad since 2007. He is the author of several articles published in the reputed national and international journals.
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Formulation and Optimization of Solid Dispersions by BoxBehnken Design
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LAP LAMBERT Academic Publishing, 2012
ISBN 10: 365915959X
ISBN 13: 9783659159596
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Formulation and Optimization of Solid Dispersions by BoxBehnken Design | Box-behnken Design - An effective tool in Solid Dispersion
Editore:
LAP Lambert Academic Publishing, 2012
ISBN 10: 365915959X
ISBN 13: 9783659159596
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Taschenbuch. Condizione: Neu. Formulation and Optimization of Solid Dispersions by BoxBehnken Design | Box-behnken Design - An effective tool in Solid Dispersion | Niranjan Chivate (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659159596 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Codice articolo 106409972
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Formulation and Optimization of Solid Dispersions by BoxBehnken Design : Box-behnken Design - An effective tool in Solid Dispersion
Editore:
LAP Lambert Academic Publishing, 2012
ISBN 10: 365915959X
ISBN 13: 9783659159596
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Da: AHA-BUCH GmbH, Einbeck, Germania
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The objective of this study was to prepare and evaluate solid dispersion of poorly water soluble drug Telmisartan, a candidate mainly from the class II category of BCS classification, to increase solubility and for enhancement of bioavailability. The solid dispersions were prepared by physical mixture method using PEG 6000, Eudrajit L 100 and PVP K 30 as a carrier. A Box Behnken design has been applied to study the effect of independent variables i.e. PEG 6000, Eudrajit L 100 and PVP K 30 on dependent variables i.e. % Cumulative Drug Release and time required for cumulative drug release . Response surface plots and counter plots were drawn and optimum formulations were selected based on feasibility search method. Validation of optimized study performed using three confirmatory runs indicated very high degree of prognostic ability of response surface methodology, with mean percentage error as +0.02. Optimized solid dispersion formulations were prepared and its effect on % Cumulative Drug Release and time was evaluated. Optimized solid dispersions were evaluated for % CDR and Time for CDR, FTIR, DSC, SEM and in vitro drug release study. Codice articolo 9783659159596
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Formulation and Optimization of Solid Dispersions by BoxBehnken Design: Box-behnken Design - An effective tool in Solid Dispersion
Editore:
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 365915959X
ISBN 13: 9783659159596
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Paperback. Condizione: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book. Codice articolo ERICA796365915959X6
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