Sustained Release Matrix Tablet of Tramadol HCl: Box-Behnken Design For Optimization of Formulation Variables of Tramadol HCl Sustained Release Matrix Tablet - Brossura

Gandhi, Chintan; Patel, Mukesh; Patel, Natvarlal

 
9783659159848: Sustained Release Matrix Tablet of Tramadol HCl: Box-Behnken Design For Optimization of Formulation Variables of Tramadol HCl Sustained Release Matrix Tablet
Brossura
ISBN 10: 3659159840 ISBN 13: 9783659159848
Casa editrice: LAP LAMBERT Academic Publishing, 2012

Sinossi

To develop sustained release matrix tablet of Tramadol HCl that deliver drug for 24 hr and to be taken once in a day. Drug having high solubility and relatively shorter half-life suggests its suitability for an extended formulation. If it is formulated by conventional tablets, it will require multiple daily administrations which ultimately results into inconveniency to the patients and possibility of reduced compliance with prescribed therapy. Also fluctuation in plasma drug concentration leads to exaggerated side effects, this all limitations can be minimized by adopting extended release formulation. To reduce the frequency of administration and to improve the patient compliance, Once in a day sustained release formulation is desirable. It describes the influence of the concentration of HPMC K4M, HPMC K15M and HPMC K100M on Tramadol HCl sustained release formulations using box-behnken design.These Polymers were selected as an independent variables. Drug release after 8 hr, 12 hr and 16 hr were selected as a dependent variables. Optimized formulation found by similarity and dissimilarity factor follow zero order kinetic with non-fickian diffusion as a drug release mechanism.

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Informazioni sull?autore

I am Mr. Chintan K. Gandhi completed M.Pharma. in Pharmaceutics from BMCPER, Modasa, Gujarat Technological University in 2012. I am an author of several articles published in reputed Journals. I worked as a Research Assistant in GVK BioScience Pvt Ltd at Ahmedabad and as a Pharmacist in Apollo Hospital Enterprises Ltd at Ahmedabad.

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Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2012
Lingua
Inglese
ISBN 10 
3659159840
ISBN 13 
9783659159848
Rilegatura
Copertina flessibile
Numero di pagine
148
Contatto del produttore
non disponibile
Persona responsabile
KreGa Onlinehandel GmbH
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