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Potential HIV Reverse Transcriptase Inhibitors: Synthesis of Benzyloxy Substituted 4,6- Diarylpyrimidine as potential HIV Reverse Transcriptase Inhibitors - Brossura
Sinossi
The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the prescribed limits so we proceeded with the synthesis of the compounds.
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L'autore
Ms. Komal Patel has obtained her Master of Pharmacy degree in Pharmaceutical Chemistry in 2010. She has published different international and National Research paper in synthetic Chemistry, Analytical Chemistry and Drug Design.
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Potential HIV Reverse Transcriptase Inhibitors : Synthesis of Benzyloxy Substituted 4,6- Diarylpyrimidine as potential HIV Reverse Transcriptase Inhibitors
Editore:
LAP Lambert Academic Publishing, 2012
ISBN 10: 3659184713
ISBN 13: 9783659184710
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Da: AHA-BUCH GmbH, Einbeck, Germania
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the prescribed limits so we proceeded with the synthesis of the compounds. Codice articolo 9783659184710
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Potential HIV Reverse Transcriptase Inhibitors
Editore:
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 3659184713
ISBN 13: 9783659184710
Nuovo
Brossura
Da: moluna, Greven, Germania
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: P. Patel KomalMs. Komal Patel has obtained her Master of Pharmacy degree in Pharmaceutical Chemistry in 2010. She has published different international and National Research paper in synthetic Chemistry, Analytical Chemistry and Drug. Codice articolo 5137842
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