Computational Analysis of Structure Function and Evolution of Serpins: Protein Conformation and Enzymology Lab Department of Biosciences JMI - Brossura

Singh, Poonam; Jairajpuri, Mohamad Aman

Brossura

ISBN 10: 3659246840 ISBN 13: 9783659246845

Casa editrice: LAP LAMBERT Academic Publishing, 2012

Riassunto

Serine Protease inhibitors like antitrypsin, antichymotrypsin, C1-inhibitor, antithrombin and plasminogen activator inhibitor, play absolutely critical role in the control of proteinases, involved in the inflammatory, complement, coagulation and fibrinolytic pathways respectively, and are associated with diseases like emphysema/cirrhosis, angioedema, familial dementia, chronic obstructive bronchitis and thrombosis. The mechanism of inhibition of serpin requires large scale conformation change and native state of serpin is in a metastable state which transforms into a stable state when they inhibit target proteases. Serpins are prone to conformational diseases due to their susceptibility to undergo point mutations especially in mobile domains that can results in aberrant intermolecular linkage and polymer formation. The effects of such protein aggregation are cumulative, with a progressive loss of cellular function. Serpin polymerization is a significant problem and devising a cure has been cumbersome owing to their complex mechanism of inhibition, metastable nature, cofactor binding ability and large scale conformational change. Critical understanding of the factors and mechanisms

Su questo libro

L'autore

I have done my schooling from KV Andrews Ganj and bachelors from Delhi University. Masters study was done at Department of Biosciences, Jamia Millia Islamia, New Delhi.I did my Ph.D under the supervision of Dr.Mohamad Aman Jairajpuri. Currently I am working as a postdoctoral research fellow in Singapore.

Dettagli dell'edizione

• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2012
• Lingua: Inglese
• ISBN 10: 3659246840
• ISBN 13: 9783659246845
• Rilegatura: Copertina flessibile
• Numero di pagine: 316
• Contatto del produttore: non disponibile
• Persona responsabile: KreGa Onlinehandel GmbH; 4950000000000; info@krega-onlinehandel.de; ; Birkenweg 31; Brakel; 33034; Germania