Computational Analysis of Structure Function and Evolution of Serpins: Protein Conformation and Enzymology Lab Department of Biosciences JMI - Brossura

Singh, Poonam; Jairajpuri, Mohamad Aman

 
9783659246845: Computational Analysis of Structure Function and Evolution of Serpins: Protein Conformation and Enzymology Lab Department of Biosciences JMI
Brossura
ISBN 10: 3659246840 ISBN 13: 9783659246845
Casa editrice: LAP LAMBERT Academic Publishing, 2012

Sinossi

Serine Protease inhibitors like antitrypsin, antichymotrypsin, C1-inhibitor, antithrombin and plasminogen activator inhibitor, play absolutely critical role in the control of proteinases, involved in the inflammatory, complement, coagulation and fibrinolytic pathways respectively, and are associated with diseases like emphysema/cirrhosis, angioedema, familial dementia, chronic obstructive bronchitis and thrombosis. The mechanism of inhibition of serpin requires large scale conformation change and native state of serpin is in a metastable state which transforms into a stable state when they inhibit target proteases. Serpins are prone to conformational diseases due to their susceptibility to undergo point mutations especially in mobile domains that can results in aberrant intermolecular linkage and polymer formation. The effects of such protein aggregation are cumulative, with a progressive loss of cellular function. Serpin polymerization is a significant problem and devising a cure has been cumbersome owing to their complex mechanism of inhibition, metastable nature, cofactor binding ability and large scale conformational change. Critical understanding of the factors and mechanisms

Le informazioni nella sezione "Riassunto" possono far riferimento a edizioni diverse di questo titolo.

L'autore

I have done my schooling from KV Andrews Ganj and bachelors from Delhi University. Masters study was done at Department of Biosciences, Jamia Millia Islamia, New Delhi.I did my Ph.D under the supervision of Dr.Mohamad Aman Jairajpuri. Currently I am working as a postdoctoral research fellow in Singapore.

Le informazioni nella sezione "Su questo libro" possono far riferimento a edizioni diverse di questo titolo.

Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2012
Lingua
Inglese
ISBN 10 
3659246840
ISBN 13 
9783659246845
Rilegatura
Copertina flessibile
Numero di pagine
316
Contatto del produttore
non disponibile
Persona responsabile
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Germania