Analytical Method Development & validation: Of Lafutidine and Domperidone - Brossura

Rana, Shefali

 
9783659281372: Analytical Method Development & validation: Of Lafutidine and Domperidone
Brossura
ISBN 10: 3659281379 ISBN 13: 9783659281372
Casa editrice: LAP LAMBERT Academic Publishing, 2012

Sinossi

We determine Lafutidine and Domperidone simultaneously by simple, rapid, accurate and precise UV-Spectroscopic methods, HPLC, and HPTLC. First Order Derivative method was based on the fact that LAF and DOM showed one zero crossing points 286.60 nm and 273.20 nm respectively. The estimation of both drugs by these two wavelength. Area under Curve Method was done by taking area under the curve in the range of 273 ± 5nm and 287.2 ± 5nm was selected for the analysis for LAF and DOM. The absorptivity values calculated. The calibration curve was plotted regression equation was calculated. HPLC method carried out by using Purospher® RP C18 (25 cm × 4.6 mm i.d., 5 μm) with mobile phase used as a combination of Methanol: Water (with TFA) pH 4.8 = 65:35. The detection was carried out at 280 nm and at flow rate of 1.0 ml/min. HPTLC method was carried out by using Precoated silica gel G60F254 Aluminum sheet, 10 x 10cm and thickness of layer 0.2mm with mobile phase used as a combination of Ethyl Acetate: Ethyl Methyl Ketone: Ammonia (3:7:0.2 v/v/v).The detection was carried out at 280 nm.The proposed methods were successfully applied for the analysis of pharmaceutical formulations.

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L'autore

She has done B.Pharm and Pursued this work while completing Master in Pharmacy (Quality Assurance) from Gujarat Technological University, Gandhinagar, Gujarat, India. “We all are very confident that her technical skills and research quest will be rewarded by great success in life"-Dr. DevangSmt. NHL Medical college, Ahmedabad, INDIA

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Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2012
Lingua
Inglese
ISBN 10 
3659281379
ISBN 13 
9783659281372
Rilegatura
Copertina flessibile
Numero di pagine
192
Contatto del produttore
non disponibile
Persona responsabile
KreGa Onlinehandel GmbH
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