Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum: Enhancement of Bioavailability by Using Natural Polymer - Brossura

Jambukiya, Vipul; Parmar, Ramesh; Sheth, N. R.

 
9783659337536: Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum: Enhancement of Bioavailability by Using Natural Polymer
Brossura
ISBN 10: 3659337536 ISBN 13: 9783659337536
Casa editrice: LAP LAMBERT Academic Publishing, 2013

Sinossi

Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBU

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L'autore

Vipul V. Jambukiya currently i am working as drug inspector at junagdha, gujarat. i did my M Pharma in Department of pharmaceutics, Saurashtra University. currently i am doing Ph. D. from Saurashtra University Under the Guidance of Dr. J. K. Patel.

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Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2013
Lingua
Inglese
ISBN 10 
3659337536
ISBN 13 
9783659337536
Rilegatura
Copertina flessibile
Numero di pagine
92
Contatto del produttore
non disponibile
Persona responsabile
non disponibile