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Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride: For Improved Efficacy Using Disintegrant Blends - Brossura

Chapla, Nikunj; Chapla, Vishal; Pujara, Naisarg

 
9783659346040: Formulation Of Fast Dissolving Tablets Of Phenylephrine Hydrochloride: For Improved Efficacy Using Disintegrant Blends
Brossura
ISBN 10: 3659346047 ISBN 13: 9783659346040
Casa editrice: LAP LAMBERT Academic Publishing, 2013

Sinossi

Recent advances in novel drug delivery system aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach is fast dissolving tablets (FDT) of Phenylephrine Hydrochloride, a selective α1 adrenergic receptor antagonist, used for nasal decongestant and producing mydriasis effect. In present work an attempt has been made by formulating fast dissolving tablets of Phenylephrine Hydrochloride by superdisintegrants addition method using croscarmellose sodium, crospovidone and sodium starch glycolate. A total of 10 batches were prepared by using various combination and concentration of superdisintegrants and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release studies, kinetic studies and stability studies. Amongst all the formulations F2 and F9 were found to be better formulations which include single superdisintegrants and combination of superdisintegrants. Finally it was concluded that FDT of Phenylephrine Hydrochloride will be used as a novel drug dosage form for pediatrics and geriatrics.

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Informazioni sull'autore

Nikunj Chapla, completed Master of Pharmacy, Pharmaceutics from Department of Pharmaceutics, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences Deralakatte, Mangalore at NITTE University.

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Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2013
Lingua
Inglese
ISBN 10 
3659346047
ISBN 13 
9783659346040
Rilegatura
Copertina flessibile
Numero di pagine
148
Contatto del produttore
non disponibile
Persona responsabile
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