Curcumin and Rheumatoid Arthritis: The effect of Curcumin on Type 17 Helper T Cells in Collagen-Induced Arthritic Rats - Brossura

Badr, Abeer; El-Wakkad, Amany; Mohsen, Elshaimaa

 
9783659784224: Curcumin and Rheumatoid Arthritis: The effect of Curcumin on Type 17 Helper T Cells in Collagen-Induced Arthritic Rats

Sinossi

Immunomodulatory imbalance is the characteristic feature of autoimmune diseases like rheumatoid arthritis (RA). T helper (Th) 17 plays a critical role in the pathogenesis of RA. The balance of Th1 and Th17 is important for normal immune response. In RA therapy, methotrexate (MTX) has an important use depending on its anti-inflammatory effects, however, is limited due to its side effects. Curcumin is a natural plant product used as an immunomodulator. The aim of this study was to investigate the impact of curcumin and MTX administration singly or combined on a rat model with collagen-induced arthritis.

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L'autore

Prof. Dr. Amany El-Wakkad is a professor immunology at Department of Medical Physiology, National Research Centre. Dr. Abeer Badr is an assistant professor of immunology at Department of Zoology, Faculty of Science, Cairo University. Elshaimaa Mohsen received her Ph.D. in immunology from Faculty of Science at Cairo University.

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