Protection & Regeneration Of Β-cells: Studies Using The Nod Mouse - Brossura

Khoo, Cheen; Pozzilli, Paolo; Alison, Malcolm

 
9783659839191: Protection & Regeneration Of Β-cells: Studies Using The Nod Mouse
Brossura
ISBN 10: 3659839191 ISBN 13: 9783659839191
Casa editrice: Scholars' Press, 2016

Sinossi

Diabetes is a chronic disease affecting approximately 250 million people. To date, transplantation-based therapy is the therapy of choice; however, its success is hampered by the scarcity of transplantable human material. An alternative strategy is the promotion of regeneration in the pancreas. Endothelial progenitor cells (EPCs), a subpopulation of bone marrow (BM) cells, can contribute to tissue repair in various pathological conditions via the formation of new blood vessels. The role and regenerative potential of EPCs in diabetes using non-obese diabetic (NOD) mice, a model of type 1 diabetes (T1D) will be discussed. In addition to promoting endogenous β-cell regeneration using EPCs, a strategy to protect β-cell death via apoptosis, using a protease peptide XG-102 developed by Xigen was investigated. In conclusion, our results shown that both therapeutic strategies showed great promise in regenerating the damaged pancreas of NOD mice. While these strategies are still under further investigation, they offer encouragement in the quest for the treatment of early diabetes in the future.

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Editore
Scholars' Press
Data di pubblicazione
2016
Lingua
Inglese
ISBN 10 
3659839191
ISBN 13 
9783659839191
Rilegatura
Copertina flessibile
Numero di pagine
208
Contatto del produttore
non disponibile
Persona responsabile
non disponibile