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Parameters of intrathymic regulatory T cell differentiation: Thymic Treg development does not require a dedicated antigen-presenting cell type but is under T cell-intrinsic control - Brossura
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The majority of regulatory T cells (Tregs) are believed to be of thymic origin. It has been hypothesized that this may result from unique intrathymic environmental cues, possibly requiring a dedicated antigen presenting cell (APC). However, T cell intrinsic developmental regulation of the susceptibility to Treg differentiation remains a mutually non-exclusive scenario. We found that upon exposure of monoclonal T cells of sequential developmental stages to a thymic microenvironment expressing cognate antigen, the efficiency of Treg induction inversely correlated with progressive maturation. In support of quantitative but not qualitative features of external cues being critical, thymic epithelial cells as well as different thymic dendritic cell (DC)-subtypes efficiently induced Treg development of immature thymocytes. We propose that the intrinsically high predisposition of immature thymocytes to Treg development may contribute to the predominantly thymic origin of the Treg repertoire. The underlying instructive stimulus, however, does not require unique features of a dedicated APC and can be delivered by hematopoietic as well as epithelial thymic stromal cells.
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Gerald Wirnsberger, Dr.rer.nat..: Diplomstudium der Genetik undBiotechnologie an der Universität Salzburg, Doktoratsstudium derMolekularbiologie an der Universität Wien, Promotion im Jahr 2009.
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Parameters of intrathymic regulatory T cell differentiation : Thymic Treg development does not require a dedicated antigen-presenting cell type but is under T cell-intrinsic control
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Südwestdeutscher Verlag für Hochschulschriften AG Co. KG, 2015
ISBN 10: 3838108493
ISBN 13: 9783838108490
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Parameters of intrathymic regulatory T cell differentiation
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Südwestdeutscher Verlag für Hochschulschriften, 2015
ISBN 10: 3838108493
ISBN 13: 9783838108490
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The majority of regulatory T cells (Tregs) are believed to be of thymic origin. It has been hypothesized that this may result from unique intrathymic environmental cues, possibly requiring a dedicated antigen presenting cell (APC). However, T cell intrinsic. Codice articolo 5405234
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Parameters of intrathymic regulatory T cell differentiation
ISBN 10: 3838108493
ISBN 13: 9783838108490
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The majority of regulatory T cells (Tregs) are believed to be of thymic origin. It has been hypothesized that this may result from unique intrathymic environmental cues, possibly requiring a dedicated antigen presenting cell (APC). However, T cell intrinsic developmental regulation of the susceptibility to Treg differentiation remains a mutually non-exclusive scenario. We found that upon exposure of monoclonal T cells of sequential developmental stages to a thymic microenvironment expressing cognate antigen, the efficiency of Treg induction inversely correlated with progressive maturation. In support of quantitative but not qualitative features of external cues being critical, thymic epithelial cells as well as different thymic dendritic cell (DC)-subtypes efficiently induced Treg development of immature thymocytes. We propose that the intrinsically high predisposition of immature thymocytes to Treg development may contribute to the predominantly thymic origin of the Treg repertoire. The underlying instructive stimulus, however, does not require unique features of a dedicated APC and can be delivered by hematopoietic as well as epithelial thymic stromal cells. 80 pp. Deutsch. Codice articolo 9783838108490
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Parameters of intrathymic regulatory T cell differentiation : Thymic Treg development does not require a dedicated antigen-presenting cell type but is under T cell-intrinsic control
Editore:
Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG, 2009
ISBN 10: 3838108493
ISBN 13: 9783838108490
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The majority of regulatory T cells (Tregs) are believed to be of thymic origin. It has been hypothesized that this may result from unique intrathymic environmental cues, possibly requiring a dedicated antigen presenting cell (APC). However, T cell intrinsic developmental regulation of the susceptibility to Treg differentiation remains a mutually non-exclusive scenario. We found that upon exposure of monoclonal T cells of sequential developmental stages to a thymic microenvironment expressing cognate antigen, the efficiency of Treg induction inversely correlated with progressive maturation. In support of quantitative but not qualitative features of external cues being critical, thymic epithelial cells as well as different thymic dendritic cell (DC)-subtypes efficiently induced Treg development of immature thymocytes. We propose that the intrinsically high predisposition of immature thymocytes to Treg development may contribute to the predominantly thymic origin of the Treg repertoire. The underlying instructive stimulus, however, does not require unique features of a dedicated APC and can be delivered by hematopoietic as well as epithelial thymic stromal cells. Codice articolo 9783838108490
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Parameters of intrathymic regulatory T cell differentiation
ISBN 10: 3838108493
ISBN 13: 9783838108490
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Taschenbuch. Condizione: Neu. Neuware -The majority of regulatory T cells (Tregs) are believed to be of thymic origin. It has been hypothesized that this may result from unique intrathymic environmental cues, possibly requiring a dedicated antigen presenting cell (APC). However, T cell intrinsic developmental regulation of the susceptibility to Treg differentiation remains a mutually non-exclusive scenario. We found that upon exposure of monoclonal T cells of sequential developmental stages to a thymic microenvironment expressing cognate antigen, the efficiency of Treg induction inversely correlated with progressive maturation. In support of quantitative but not qualitative features of external cues being critical, thymic epithelial cells as well as different thymic dendritic cell (DC)-subtypes efficiently induced Treg development of immature thymocytes. We propose that the intrinsically high predisposition of immature thymocytes to Treg development may contribute to the predominantly thymic origin of the Treg repertoire. The underlying instructive stimulus, however, does not require unique features of a dedicated APC and can be delivered by hematopoietic as well as epithelial thymic stromal cells.Books on Demand GmbH, Überseering 33, 22297 Hamburg 80 pp. Deutsch. Codice articolo 9783838108490
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Parameters of intrathymic regulatory T cell differentiation | Thymic Treg development does not require a dedicated antigen-presenting cell type but is under T cell-intrinsic control
Editore:
Südwestdeutscher Verlag für Hochschulschriften AG Co. KG, 2015
ISBN 10: 3838108493
ISBN 13: 9783838108490
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Taschenbuch. Condizione: Neu. Parameters of intrathymic regulatory T cell differentiation | Thymic Treg development does not require a dedicated antigen-presenting cell type but is under T cell-intrinsic control | Gerald Wirnsberger | Taschenbuch | 80 S. | Deutsch | 2015 | Südwestdeutscher Verlag für Hochschulschriften AG Co. KG | EAN 9783838108490 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. Codice articolo 101491438
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Parameters Of Intrathymic Regulatory T Cell Differentiation: Thymic Treg Development Does Not Require A Dedicated Antigen-Presenting Cell Type But Is Under T Cell-Intrinsic Control
Editore:
Südwestdeutscher Verlag Für Hochschulschriften, 2009
ISBN 10: 3838108493
ISBN 13: 9783838108490
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Paperback. Condizione: Brand New. 80 pages. German language. 8.35x5.83x0.39 inches. In Stock. Codice articolo 3838108493
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