Development of Colon Targeted Hydrogel Tablet of Methotrexate: Development And Characterization of Colon Targeted Hydrogel Tablet of Methotrexate - Brossura

Patel, Mukesh; Patel, Natvarlal; Patel, Kanu

 
9783846544969: Development of Colon Targeted Hydrogel Tablet of Methotrexate: Development And Characterization of Colon Targeted Hydrogel Tablet of Methotrexate
Brossura
ISBN 10: 3846544965 ISBN 13: 9783846544969
Casa editrice: LAP LAMBERT Academic Publishing, 2012

Sinossi

Colorectal cancer is second leading cause of deaths in the United States. Various approaches available for The poor site specificity of pH dependent systems, because of large variation in the pH of gastrointestinal tract, was well established. The timed-release systems release their load after a predetermined period of administration. These are designed to resist the release of the drug in stomach and small intestine and release of the drug takes place in colon. Methotrexate (MTX) is a used in the treatment of colon cancer and now a days rheumatic disease. MTX is a folate antimetabolite. MTX has since been used in the treatment of various malignancies including osteosarcoma, non-Hodgkin's lymphoma, Hodgkin's disease, cutaneous T cell lymphoma, lung cancer, colon cancer and breast cancer. The conventional dosage forms which are used for colorectal cancer normally dissolve and absorbs in the stomach and small intestine; thus a very less quantity of dose of drug reaches to colonic region. Aim of present work is to develop and characterize colon targeted tablet of MTX for for treatment of colorectal cancer using different polymer and excipient by compression coating technology.

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L'autore

DR. Mukesh R Patel did B.Pharm from N M University & M.Pharm From Rajiv Gandhi University and doctorate from H N G University, Gujarat, India. He started his carrier as a Lecturer and currently working as associate professor and HOD in Pharmaceutics at BMCPER, Modasa. He has Published number of Research Papers in National and International journals

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Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2012
Lingua
Inglese
ISBN 10 
3846544965
ISBN 13 
9783846544969
Rilegatura
Copertina flessibile
Numero di pagine
128
Contatto del produttore
non disponibile
Persona responsabile
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