Impurity Profiling of a New Drug Entity: Experimental Insights - Brossura

Mishra, Neeraj; Baldi, Ashish; Rawal, Ravindra K.

Brossura

ISBN 10: 3846580120 ISBN 13: 9783846580127

Casa editrice: LAP Lambert Acad. Publ., 2014

Riassunto

Impurity profiling and drug degradation pathways are essentials features for regulatory acceptance of any new drug entity. Despite of technological advancements in pharmaceutical analysis, structural elucidation of drug molecules, impurities produced during formulation remains challenging tasks for researchers. Unique chemical behavior, complex properties and interactions of different functional groups involved in active pharmaceutical ingredients along with different chemical environments with excipients and storage condition further complicate the issues. Furthermore isolation and characterization of impurities with special references to toxic metabolites is essential for acceptance of new drug molecules by regulatory agencies. Recently discovered and patented nitrate esters of paracetamol having improved analgesic and anti-inflammatory activities then parent drug and less hepatotoxicity in overdose is selected as model drug entity. This book is an attempt to provide experimental insights into the chemical, analytical and establishment of drug degradation pathways in forced conditions in lucid manner for easy understanding to meet future expectations of scientific fraternities.

Dettagli dell?edizione

• Editore: LAP Lambert Acad. Publ.
• Data di pubblicazione: 2014
• Lingua: Inglese
• ISBN 10: 3846580120
• ISBN 13: 9783846580127
• Rilegatura: Copertina flessibile
• Numero di pagine: 80
• Contatto del produttore: non disponibile
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