Ambroxol HCl SR Tablet: Formulation Development and Evaluation - Brossura

Akhter, Dewan Taslima; Huda, Naz Hasan; Ahmed, Tajnin

Brossura

ISBN 10: 3847346067 ISBN 13: 9783847346067

Casa editrice: LAP LAMBERT Academic Publishing, 2012

Riassunto

The purpose of the present investigation was to design and evaluate sustained release tablets of a sparingly water soluble drug Ambroxol Hydrochloride, two hydrophilic polymers METHOCEL K15MCR and METHOCEL K100MCR and hydrophobic Eudragit RL100 were used in tablets prepared by direct compression. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity and drug content. The tablets were subjected to various tests for physical parameters such as thickness, hardness and friability, and in vitro release studies. The in vitro dissolution study was carried out for 12 hours using United States Pharmacopoeia (USP) paddle-type dissolution apparatus (Apparatus 2) in phosphate buffer (pH 6.8). The results of dissolution studies indicated that formulations containing Methocel K100 MCR showed better dissolution properties compared to formulaitons containing Methocel K15 MCR.It was found that Hydrophilic polymers showed better released profile than the hydrophobic polymers.

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Informazioni sull?autore

Dewan Taslima Akhter has obtained her BPharm (Hons.) and MS degree from Jahangirnagar University. Naz H. Huda is graduated from Khulna University and obtained MS degree from United Kingdom. Tajnin Ahmed has obtained her M.Pharm degree from USTC. Authors are Pharmacists and currently working in Department of Pharmacy, Stamford University Bangladesh.

Dettagli dell?edizione

• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2012
• Lingua: Inglese
• ISBN 10: 3847346067
• ISBN 13: 9783847346067
• Rilegatura: Copertina flessibile
• Numero di pagine: 140
• Contatto del produttore: non disponibile