The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma - Brossura

Karsy, Michael

Brossura

ISBN 10: 3848487535 ISBN 13: 9783848487530

Casa editrice: LAP LAMBERT Academic Publishing, 2014

Riassunto

Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been observed in GBM, such as loss of PTEN and NF1, EGFR amplification, as well as p53 mutation, which may be involved in the regulation of CSCs in GBM. This book showed that a codon-specific p53 mutation is associated with the tumorigenesis of GBM as well as regulation of CSC self-renewal and differentiation. In addition, the PTEN/AKT/mTOR and Ras/ERK1/2 signaling pathways are associated with gliomagenesis. Lastly, GBM cells are affected by therapeutic agents, including inhibitors of mTOR, PI3K and ERK1/2, along with arsenic trioxide (ATO) and all- trans retinoic acid (ATRA). The findings of this study highlight the significance of mutant p53, the role of the MAPK and mTOR signaling pathways in the regulation of CSCs, as well as the potential of ATO and ATRA as targeted treatments of GBM.

Dettagli dell'edizione

• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2014
• Lingua: Inglese
• ISBN 10: 3848487535
• ISBN 13: 9783848487530
• Rilegatura: Copertina flessibile
• Numero di pagine: 256
• Contatto del produttore: non disponibile
• Persona responsabile: KreGa Onlinehandel GmbH; 4950000000000; info@krega-onlinehandel.de; ; Birkenweg 31; Brakel; 33034; Germania