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Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles
Print on DemandDa: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The oral bioavailability of a drug substance is strongly related to its aqueous solubility.Only complete dissolution during the GI-passage can maintain an optimalbioavailability. Poor aqueous drug solubility results, according to the Nernst-Brunnerequation into a slow dissolution rate, sometimes too slow for complete dissolution inthe GI tract. The dissolution rate increases with decreasing particle size and thereforeincreasing surface area of the drug particles. In consequence, micronization of thedrug is applied to increase oral bioavailability, but often meets with modest success.Recently developed techniques were applied to decrease the particle size into thenanometer range. For some substances, pharmacokinetic parameters could beinfluenced decisively, e.g. the obviation of a food effect for the drugs aprepitant andfenofibrate. 200 pp. Englisch. Codice articolo 9783954040001
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Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles
Print on DemandDa: moluna, Greven, Germania
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. KlappentextrnrnThe oral bioavailability of a drug substance is strongly related to its aqueous solubility.nOnly complete dissolution during the GI-passage can maintain an optimalnbioavailability. Poor aqueous drug solubility results, according t. Codice articolo 70661906
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Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles
Print on DemandDa: buchversandmimpf2000, Emtmannsberg, BAYE, Germania
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Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The oral bioavailability of a drug substance is strongly related to its aqueous solubility.Only complete dissolution during the GI-passage can maintain an optimalbioavailability. Poor aqueous drug solubility results, according to the Nernst-Brunnerequation into a slow dissolution rate, sometimes too slow for complete dissolution inthe GI tract. The dissolution rate increases with decreasing particle size and thereforeincreasing surface area of the drug particles. In consequence, micronization of thedrug is applied to increase oral bioavailability, but often meets with modest success.Recently developed techniques were applied to decrease the particle size into thenanometer range. For some substances, pharmacokinetic parameters could beinfluenced decisively, e.g. the obviation of a food effect for the drugs aprepitant andfenofibrate. 200 pp. Englisch. Codice articolo 9783954040001
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Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles
Print on DemandDa: AHA-BUCH GmbH, Einbeck, Germania
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The oral bioavailability of a drug substance is strongly related to its aqueous solubility.Only complete dissolution during the GI-passage can maintain an optimalbioavailability. Poor aqueous drug solubility results, according to the Nernst-Brunnerequation into a slow dissolution rate, sometimes too slow for complete dissolution inthe GI tract. The dissolution rate increases with decreasing particle size and thereforeincreasing surface area of the drug particles. In consequence, micronization of thedrug is applied to increase oral bioavailability, but often meets with modest success.Recently developed techniques were applied to decrease the particle size into thenanometer range. For some substances, pharmacokinetic parameters could beinfluenced decisively, e.g. the obviation of a food effect for the drugs aprepitant andfenofibrate. Codice articolo 9783954040001
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Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles
Print on DemandDa: preigu, Osnabrück, Germania
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Taschenbuch. Condizione: Neu. Analytics of dissolution testing of products containing nanosized drugs with a view to predicting plasma profiles | Daniel Jünemann | Taschenbuch | Englisch | 2012 | Cuvillier | EAN 9783954040001 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu Print on Demand. Codice articolo 104319233
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