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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones - Brossura
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We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits.
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model
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Scholars' Press Dez 2022, 2022
ISBN 10: 6138976460
ISBN 13: 9786138976462
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Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
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Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits. 164 pp. Englisch. Codice articolo 9786138976462
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model
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Condizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. We evaluated the fluoroquinolones levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxic. Codice articolo 791057876
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model : Evaluation of Retinopathic Potential of Fluoroquinolones
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Taschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits. Codice articolo 9786138976462
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model | Evaluation of Retinopathic Potential of Fluoroquinolones
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Taschenbuch. Condizione: Neu. Retinopathic Potential of Fluoroquinolones Using Rabbit as Model | Evaluation of Retinopathic Potential of Fluoroquinolones | Adil Mehraj Khan (u. a.) | Taschenbuch | Englisch | 2022 | Scholars' Press | EAN 9786138976462 | Verantwortliche Person für die EU: SIA OmniScriptum Publishing, Brivibas Gatve 197, 1039 RIGA, LETTLAND, customerservice[at]vdm-vsg[dot]de | Anbieter: preigu. Codice articolo 126348292
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model
Editore:
Scholars' Press Dez 2022, 2022
ISBN 10: 6138976460
ISBN 13: 9786138976462
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Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania
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Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 164 pp. Englisch. Codice articolo 9786138976462
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