Formulation and Development of Bilayer Floating Tablets of Nifedipine: Formulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique - Brossura

Sharma, Dinesh Kumar; Behera, Amulyaratna; Pattnaik, Gurudutta

 
9786203410877: Formulation and Development of Bilayer Floating Tablets of Nifedipine: Formulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique
Brossura
ISBN 10: 620341087X ISBN 13: 9786203410877
Casa editrice: LAP LAMBERT Academic Publishing, 2021

Sinossi

The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.

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Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2021
Lingua
Inglese
ISBN 10 
620341087X
ISBN 13 
9786203410877
Rilegatura
Copertina flessibile
Numero di pagine
108
Contatto del produttore
non disponibile
Persona responsabile
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