Diclofenac Potassium Tablet for Colon Targeting: Formulation: Diclofenac Potassium Tablet for Colon Targeting - Brossura

Shinde, Anilkumar; Jarag, Ravindra; More, Harinath

 
9786206181217: Diclofenac Potassium Tablet for Colon Targeting: Formulation: Diclofenac Potassium Tablet for Colon Targeting
Brossura
ISBN 10: 6206181219 ISBN 13: 9786206181217
Casa editrice: LAP LAMBERT Academic Publishing, 2023

Sinossi

The present study was to formulate tablet of Diclofenac potassium using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC), Hydroxypropyl Cellulose (HPC), Ethyl Cellulose(N22), Cross Povidone and Sodium Starch Glycolate as a superdisintegrants and Instacoat EN super II as a enteric coat to the colone specific tablet. A 33 randomized full factorial design, 3 level and 3 factors were used. The concentration of Hydroxy propyl cellulose (X1), concentration of HPMC K4M (X2) and concentration of Ethyl cellulose (X3) were selected as independent variables. The percentage drug release at 12 hours (Q12), percentage friability and hardness of tablet were selected as dependent variables for optimization study. The core, press coat tablets were compressed by rotatory tablet machine evaluated with different parameters like diameter, thickness, average weight, hardness, friability, kinetic release data. Hardness of tablets was found to be in the range of 7–8 kg/cm2. The enteric coated tablets containing diclofenac potassium released 38.12 % at the end of 12 hrs by in vitro release study.

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Editore
LAP LAMBERT Academic Publishing
Data di pubblicazione
2023
Lingua
Inglese
ISBN 10 
6206181219
ISBN 13 
9786206181217
Rilegatura
Copertina flessibile
Numero di pagine
52
Contatto del produttore
non disponibile
Persona responsabile
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