Advanced Mass Spectrometry-based Analytical Separation Techniques for Probing the Polar Metabolome

Lingua: inglese

Editore: Royal Society of Chemistry, GB, 2021

1839161639 / 9781839161636

Da: Rarewaves USA, HEBRON, KY, U.S.A.Rarewaves USA

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The efficient analysis of polar and charged metabolites in biological samples remains a huge challenge in the field of metabolomics. Over the past years, novel mass spectrometry-based analytical tools have been developed to enable the sensitive and efficient profiling of polar ionogenic metabolites in various biological samples. This book gives the reader a comprehensive overview of these recent technological developments. Topics covered include the use of chemical labelling strategies for allowing the analysis of polar metabolites using reversed-phase liquid chromatography-mass spectrometry (RPLC-MS) and the latest methodological developments in RPLC-MS, hydrophilic interaction liquid chromatography (HILIC)-MS and ion-pair LC-MS approaches. Attention is also paid to developments in nano-LC-MS and capillary electrophoresis-mass spectrometry methods specifically for profiling polar metabolites in small volume biological samples. The utility of ion-mobility MS and NMR spectroscopy will also be outlined. Sample preparation is the key part in the analytical workflow employed for metabolomics. Therefore, ample emphasis will be given on recent solid-phase extraction and solid-phase micro-extraction methods. Finally, analytical techniques for chiral metabolic profiling will also be considered. Discussing the state-of-the-art of the proposed topics in one single book for probing the polar metabolome, using relevant examples, is unique and needed in the metabolomics field. This book has relevance and appeal to an international audience of analytical and biomedical researchers in industry and academia.

Codice articolo LU-9781839161636

Titolo
Advanced Mass Spectrometry-based Analytical Separation Techniques for Probing the Polar Metabolome
Autore
Rawi Ramautar
Editore
Royal Society of Chemistry, GB
Anno di pubblicazione
2021
Condizione
New
Rilegatura
Hardback
Lingua
inglese
ISBN 10
1839161639
ISBN 13
9781839161636
Peso dell'articolo
704 grammi

Rarewaves USA

HEBRON, KY, U.S.A.

Venditore con 5 stelle

Venditore AbeBooks dal 10 giugno 2025

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