Advancing Methods for Biomolecular Crystallography

Randy Read

ISBN 10: 9400762313 / ISBN 13: 9789400762312

Editore: Springer Netherlands, Springer Netherlands, 2013

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Druck auf Anfrage Neuware - Printed after ordering - This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web. Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis. These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome. Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.

Codice articolo 9789400762312

Dati bibliografici

• Titolo: Advancing Methods for Biomolecular Crystallography
• Editore: Springer Netherlands, Springer Netherlands
• Data di pubblicazione: 2013
• Lingua: Inglese
• ISBN 10: 9400762313
• ISBN 13: 9789400762312
• Rilegatura: Buch
• Condizione: Neu
• Dimensioni: 241 L x 160 A x 25 P (millimetri) 241 millimetri di larghezza per 160 millimetri di altezza per 25 millimetri di profondità
• Peso: 729 grammi

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Riassunto

This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web. Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis. These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome. Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.