Alcohol, Cell Membranes, and Signal Transduction in Brain (Paperback)

Christer Alling

ISBN 10: 1461360528 / ISBN 13: 9781461360520

Editore: Springer-Verlag New York Inc., New York, NY, 2012

Paperback. Alcohol abuse and alcoholism are international problems whose costs economical ly, psychologically and medically have been well documented. Alcohol is a unique drug in that the effects of excessive use can have a deleterious effect on most if not all organs of the body. The brain is one of the organs most affected by excessive alcohol consumption. Effects on the brain can be seen in cognitive function, brain structure and neurochemistry. Over the past few years, there have been significant advances made in understanding how alcohol affects brain neurochemistry. This book examines four major areas, i. e. , membrane lipids, receptors and ion channels, second messengers, and gene expression, where significant advancements have been made. The book is divided into four sections based on the four major areas. In each section, data are examined that cover a range of approaches from in vitro to in vivo studies. The section on membrane lipids includes recent developments in how ethanol affects membrane cholesterol domains, polyunsaturated fatty acids, the cause and consequences of phosphatidylethanol formation, and the modulation of membrane protein function by lipid-protein interaction. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. Codice articolo 9781461360520

Riassunto:

Alcohol abuse and alcoholism are international problems whose costs economical­ ly, psychologically and medically have been well documented. Alcohol is a unique drug in that the effects of excessive use can have a deleterious effect on most if not all organs of the body. The brain is one of the organs most affected by excessive alcohol consumption. Effects on the brain can be seen in cognitive function, brain structure and neurochemistry. Over the past few years, there have been significant advances made in understanding how alcohol affects brain neurochemistry. This book examines four major areas, i. e. , membrane lipids, receptors and ion channels, second messengers, and gene expression, where significant advancements have been made. The book is divided into four sections based on the four major areas. In each section, data are examined that cover a range of approaches from in vitro to in vivo studies. The section on membrane lipids includes recent developments in how ethanol affects membrane cholesterol domains, polyunsaturated fatty acids, the cause and consequences of phosphatidylethanol formation, and the modulation of membrane protein function by lipid-protein interaction. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels.

Contenuti: Lipid Structure, Domains, and Proteins: Molecular Mechanisms of Ethanol and Anesthetic Actions (C.D. Stubbs, E. Rubin). Membrane Cholesterol and Ethanol (W.G. Wood et al.). The Effects of Ethanol on Polyunsaturated Fatty Acid Composition (N. Salem, Jr., G. Ward). Receptors and Ion Channels: Sensitivity of NMDA Receptors to Acute and in Utero Ethanol Exposure (S.W. Leslie, M.S. Weaver). Molecular Mechanisms of Alcohol Neurotoxicity (F.T. Crews et al.). Second Messenger Systems and Kinases: Nucleoside Transport and EthanolInduced Heterologous Desensitization (A. Gordon et al.). Ethanol and Phospholipid Dependent Signal Transduction (J.B. Hoek et al.). Gene Expression: Regulation of Neuronal Gene Transcription by Ethanol (M.F. Miles et al.). Effect of Acute and Chronic Administration of Ethanol on cfos Expression in Brain (F. Le et al.). 19 additional articles. Index.

Dati bibliografici

Titolo: Alcohol, Cell Membranes, and Signal ...
Casa editrice: Springer-Verlag New York Inc., New York, NY
Data di pubblicazione: 2012
Legatura: Paperback
Condizione: new