Angiogenesis in Health and Disease - Basic Mechanisms and Clinical Applications

Outlines strategies for stimulating capillary formation in hypoxia and ischemia and inhibiting it in cancer, diabetes, and chronic inflammation.
This state-of-the-science reference highlights recent progress in the ways to promote formation of new blood vessels in ischemic/hypoxic tissue and the means to stifle capillary growth and development in solid tumors, diabetic retinopathy, and chronic immuno/inflammatory disorders such as rheumatoid arthritis and psoriasis.
Emphasizes practical clinical applications derived from the latest angiogenesis research.
Written by over 80 leading international experts, Angiogenesis in Health and Disease

examines new angiogenic regulators such as angiopoietins and TIE-receptors

describes angiogenic genes such as thymosine B-4, EDG-1, and ARNT proteins

analyzes the role of vascular endothelial growth factor (VEGF) in capillary sprouting

investigates behaviors of endogenous agents of angiogenesis, including cytokines, hormones, chemokines, and peptide and hematopoietic growth factors

explores mechanisms for ameliorating or preventing vascular occlusive disease by induction of collateral artery growth

explains differences in conditions that prompt angiogenesis and arteriogenesis

reviews transgenic and knock-out mice, receptor protein mutations, and other emerging technologies

evaluates angiogenic inhibitors such as angiostatin and endostatin

and more!
Containing over 3000 references, tables, drawings, and photographs, Angiogenesis in Health and Disease deserves a prominent place on the bookshelves of cardiologists, oncologists, physiologists, hematologists, molecular and cell biologists, biochemists, pharmacologists, rheumatologists, vascular surgeons, and upper-level undergraduate, graduate, and medical school students in these disciplines.

Blood Vessels and Development

Molecular Biology of Vasculogenesis and Early Angiogenesis,
Ingo Flamme
Arteriogenesis, Collateral Blood Vessels, and Their Development,
Elisabeth Deindl, Borja Fernández, Imo E. Höfer, Niels van Royen, Dimitri Scholz, and Wolfgang Schaper

Angiogenic Growth Factors and Their Receptors

The Role of Vascular Endothelial Growth Factor in Angiogenesis,
Napoleone Ferrara
Fibroblast Growth Factors and Their Receptors,
Andrew Baird
TIE-2 Signaling and Venous Malformations,
Leena Karttunen, Miikka Vikkula, Laurence M. Boon, and Bjorn R. Olsen

Novel Angiogenic Genes

Novel Autocrine and Paracrine Regulators of the Angiogenic Cascade,
Hellmut G. Augustin
Thymosin 4 in Endothelial Cell Differentiation,
Derrick S. Grant and R. Wesley Rose
EDG-1, an Endothelial-Derived G Protein-Coupled Receptor for Bioactive Lipids, Regulates Morphogenetic Differentiation,
Menq-Jer Lee, Shobha Thangada, Catherine H. Liu, Brian Thompson, Nicolas Ancellin, Michael Kluk, and Timothy Hla
The Role of HIF-1 and ARNT Proteins in Blood Vessel Development,
Emin Maltepe and M. Celeste Simon
Scatter Factor as a Tumor Angiogenesis Factor,
Eliot M. Rosen, Katrin Lamszus, John Laterra, Peter J. Polverini, Saijun Fan, and Itzhak D. Goldberg
Thromboxane A2 as an Antiangiogenic Factor,
Anthony W. Ashton and J. Anthony Ware

Modulators of Angiogenesis

Modulation of Endothelial Cell Function by Estrogen,
H. William Schnaper, Maria Luiza C. Albuquerque, John McGuire, Seunghee Kim-Schulze, Constance Runyan, and Susan C. Hubchak
Nitric Oxide and Angiogenesis,
Anthony Jones and Stefan Zöllner
Reactive Oxygen Species and Angiogenesis,
Peter I. Lelkes and Christopher R. Waters
Modulators of Angiogenesis: Hemodynamic Forces,
Olga Hudlicka and Margaret D. Brown
Oxygen and Tumor Angiogenesis,
Yuval Dor and Eli Keshet
Fibrin and Proteolysis in Repair-Associated Angiogenesis,
Pieter Koolwijk and Victor W. M. van Hinsbergh
The Role of E-Selectin in Tumor Angiogenesis and Metastasis,
Jing-Liang Wang, James S. Tomlinson, and Mai Nguyen

Animal Models of Angiogenesis

In Vitro and In Vivo Models of Angiogenesis,
Hynda K. Kleinman, Katherine M. Malinda, Yong Song Gho, and M. Lourdes Ponce
Considerations for Angiogenic Tumor Models,
William E. Fogler and Stacy M. Plum

Inhibition of Angiogenesis in Experimental Models

Thrombospondin-1 Modulates Angiogenesis and Tumor Progression: New Targets for Antiangiogenesis Therapy,
Anitha S. John and George P. Tuszynski
Inhibition of VEGF Receptor Tyrosine Kinase,
Gerhard Siemeister, Andreas Menrad, Michael Schirner, Karl-Heinz Thierauch, Georg Martiny-Baron, Dieter Marmé, Guido Bold, Johannes Rösel, Jeanette M. Wood, and Martin R. Schneider
Antiangiogenic Function of Thrombospondin-1,
M. Luisa Iruela-Arispe, Maria Asunción Ortega, and Francisca Vázquez

Clinical Applications of Antiangiogenic Therapy in Cancer

Thalidomide,
Erwin A. Kruger, Eddie Reed, and William D. Figg
CM101,
Russell F. DeVore III
TNP-470,
Pankaj Bhargava, Margaret S. Dordal, and Michael J. Hawkins

Inflammation, Wound Healing, and Rheumatoid Arthritis

Chronic Inflammation and Angiogenesis,
James D. Winkler and Jeffrey R. Jackson
Angiogenic Mediators in Healing Wounds,
Nicholas N. Nissen and Luisa A. DiPietro
Angiogenesis in Rheumatoid Arthritis,
Zoltan Szekanecz and Alisa E. Koch

Therapeutic Angiogenesis in Ischemia

Growth Factor Therapy in Ischemic Heart Disease,
Roger J. Laham and Michael Simons
Cerebral Ischemia,
Alan Z. Segal and Seth P. Finklestein
Therapeutic Angiogenesis,
Jeffrey M. Isner and Takayuki Asahara
Lessons to Be Learned from Clinical Trials of Angiogenesis Modulators in Ischemic Diseases,
William W. Li, Michael Jaffe, Dimitris Tsakayannis, and Vincent W. Li