Riassunto
Written by two renowned authorities who specialize in the treatment of breast cancer, a surgeon and an oncologist, this is the one indispensable book women need in order to cope with a disease that will strike one out of every nine of them in the United States.
Now revised to bring readers the very latest information on diagnosis and treatment, this lucid step-by-step guide contains all the latest information women require if they are to collaborate with their doctors in making truly informed decisions about the care that is right for them.
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HOW DO I KNOW WHICH TYPE OF SURGERY IS RIGHT FOR ME?
Our basic job is to get rid of the cancer and prevent its spread and recurrence, if possible while preserving the breast. In order to accomplish that task, we have to understand the nature or pathology of the malignancy; its stage, including its size and how much it has spread; its location in the breast; and the size of the breast itself. We also have to give serious consideration to what you yourself prefer.
The following sections describe the general circumstances under which each type of surgery is appropriate.
Stage 0 Cancer
Stage 0 cancers are noninfiltrating cancers confined to the lobules and ducts.
Lobular carcinoma in situ (LCIS), generally speaking, requires no surgery after the biopsy. It should, however, be very carefully watched. Mammography and a physical examination by a doctor should be regularly scheduled because this in situ cancer is what we call a marker of great risk. Twenty percent of women with this symptom develop infiltrating cancers over a twenty-year period and there is a likelihood that both breasts are at risk.
In the past, duct cell carcinoma in situ (DCIS) was usually discovered after a biopsy for a nipple discharge or ulceration. With the recent improvements in mammography, we are able to pick up very early abnormalities, and now over twenty percent of the women we treat for breast cancer have DCIS.
To treat DCIS, we do a total mastectomy (without lymph node removal) or we do a lumpectomy followed by radiation therapy. Which procedure to choose poses a dilemma. We know that if we treat DCIS with mastectomy, we can achieve close to one hundred percent success. If we preserve the breast with a wide excision and radiotherapy, there is a one-percent-a-year recurrence rate. Of those women who have a recurrence, half can be successfully treated with mastectomy. The other half will have infiltrating disease. Some of them will be cured, but some lives will be lost.
Many women and their doctors say, "If there is any risk of recurrence at all, do a mastectomy." Others decide that one percent a year is an acceptable risk. They are opting for as wide an excision as can be done to avoid deformity, along with radiation therapy.
As we will see below, invasive cancers are treated with lumpectomy, node removal, and radiation. It seems paradoxical that cases of DCIS--that is, of noninvasive cancer--are often treated with mastectomy because of the one hundred percent cure rate. As one of my patients said, "Is the loss of my breast the reward I get for finding cancer before it has spread?"
There are studies now under way to try to resolve this dichotomy, and to find out whether, in some cases of DCIS, wide excision alone is adequate treatment. In the meantime, if you have an in situ ductal cancer, you and your doctor will have to carefully discuss and weigh your treatment options We are not yet at the point where, as in early lobular cancers, we can monitor and observe and, at least, delay surgery. But treatment for intraductal carcinomas in situ can and should be individualized and the options carefully weighed as to their physical and emotional consequences.
Stage I and Stage II Cancers
The discussion of treatment for these cancers is best begun with a quote from "the horse's mouth," a conference convened by the National Institutes of Health (NIH) to evaluate available scientific information and to "resolve safety and efficacy issues related to biomedical technology." According to the findings of this NIH Consensus Conference on early, invasive breast cancer, in June 1990, "Breast conservation treatment is an appropriate method of primary therapy for the majority of women with Stages I and II breast cancer and is preferable because it provides survival rates equivalent to those of total mastectomy [modified radical] and axillary dissection while preserving the breast."
To clarify, lumpectomy with axillary dissection and radiation therapy is the preferable treatment for small infiltrating cancers of either the lobules or the ducts.
There are, however, circumstances where mastectomy is the treatment advised for Stage I and Stage II cancers:
More than one cancerous tumor in the breast
Multiple areas of microcalcification (see page 77) in the breast
A relatively large tumor in a small breast or a tumor in or near the center of the breast
Considerable axillary lymph-node involvement
In addition, some physicians consider mastectomy the preferred treatment in the following circumstances:
Extensive intraductal cancer in situ within and adjacent to the primary tumor
An infiltrating cancer plus a considerable amount of intraductal cancer
Under certain circumstances, we may recommend a bilateral mastectomy when there is lobular cancer in situ:
If there have been recurrent lumps that required biopsy
If mammograms show calcifications that are difficult to interpret
If there is an extremely strong family history of breast cancer
Stage III Cancers
We have, up until now, been discussing early, relatively small cancers. As we saw in Chapter Three, some women come for treatment with more advanced disease. In such cases, the cancer may be in the skin of the breast, it may be of the inflammatory type, it may be accompanied by extensive lymph-node involvement, or the tumor may be over five centimeters (about two inches) in size.
For Stage III cancers, chemotherapy (see Chapter Ten) is the first treatment. It is used to treat inflammatory cancer and also to shrink a large tumor to operable size. Surgery, usually a modified radical mastectomy, is performed after the tumor has shrunk.
Stage IV Cancers
Stage IV cancers have spread beyond the breast and the axillary lymph nodes to other places in the body. They are treated primarily with chemotherapy. Surgery--lumpectomy or modified radical mastectomy--or radiation therapy may sometimes be used to assist in local tumor control.
It is important to say here that I have patients in my practice who came to me with a large tumor and who have done well, usually with chemotherapy followed by surgery. In a few instances, where the tumor was inoperable, some women have survived for many years on long-term chemotherapy.
Cancer in Pregnancy
As we saw in Chapter Three, breast cancer in pregnant women tends to be discovered at a later stage than cancer in other women. Our general approach is to "abort the cancer, not the baby." However, when cancer is discovered during the first trimester, women usually choose to terminate the pregnancy and then to promptly seek the most appropriate treatment for the disease.
During the second trimester or later, a mastectomy can be safely performed. We do not use radiation with pregnant women so as not to risk the well-being of the fetus. Chemotherapy may be started only in the very last weeks of pregnancy.
Treatment Options
To summarize the sequence of treatment that may be recommended for all stages of breast cancer:
STAGE 0
LOBULAR CARCINOMA IN SITU
1. Biopsy
2. Observation
3. Possible hormone therapy
or
1. Bilateral mastectomy
2. Breast reconstruction
DUCTAL CARCINOMA IN SITU
1. Biopsy
2. Mastectomy
or
1. Wide excision with observation only (experimental)
or
1. Wide excision plus radiation
STAGE I
1. Biopsy
2. Partial (lumpectomy) or modified radical mastectomy
3. Axillary dissection
4. If mastectomy, possible breast reconstruction
5. If lumpectomy, radiation therapy
6. Possible hormone therapy or chemotherapy
STAGE II
1. Biopsy
2. Lumpectomy or modified radical mastectomy
3. Axillary dissection
4. If mastectomy, possible breast reconstruction
5. If lumpectomy, radiation therapy
6. Hormone therapy or chemotherapy
STAGE III
1. Biopsy
2. Course of chemotherapy
3. Modified radical mastectomy
4. Continued chemotherapy
5. Radiation therapy
STAGE IV
1. Biopsy
2. Course of chemotherapy
3. If appropriate, lumpectomy
or
Modified radical mastectomy
4. Continued chemotherapy
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