Biomaterial-based Additive Manufacturing in Tissue Engineering and Regeneration

Biomaterials are substances that are engineered to interact with biological systems for medical and therapeutic purposes. Biomaterial-based additive manufacturing in tissue engineering is a rapidly evolving ­ field with ongoing research and development. As technology advances, it is likely to play a pivotal role in the development of regenerative medicine and personalized healthcare. Biomaterial-based additive manufacturing, also known as 3D bioprinting utilizing biodegradable or bioavailable polymeric materials, is a cutting-edge technology with great potential and promise for tissue engineering and regeneration. This innovative approach combines biomaterial or engineered biomaterials with precise or customized printing to develop a complex three-dimensional structure that mimics the architecture and functionality of native tissues. An important aspect in development of 3D printed products for tissue engineering or regeneration is selection of biomaterials, development of bio inks using those biomaterials, cell integration, customization, vascularization, and biodegradability of the product. Although 3D bioprinting has shown promise in various applications with potential to revolutionize organ transplantation and tissue engineering, there are several challenges such as ensuring proper vascularization, improving the mechanical properties of printed products, and addressing regulatory aspects with ethical consideration. Therefore, in this book emphasis on tissue engineering and regeneration will be presented, which is an interdisciplinary ­ field that aim to restore, repair, or replace damaged or lost biological tissues. Moreover, chapters inform on recent shift in research that indicates a customized fabrication of biodegradable products, the future of tissue engineering and regeneration.

Dr. Sudarshan Singh, a Ph.D. in pharmaceutical sciences and presently working as a Frontier Proactive Researcher at the Faculty of Pharmacy, Chiang Mai University, Thailand. His current research is focused on utilization of bioinspired polymeric materisl via additive manufacturing in fabrication of composite fortified to counteract the effect of dermal inflammation followed cellular bioassay, intracellular uptake, and the development of engineered multifunctional nature originated biomaterials for incorporating them in various drug delivery. Whereas previous research investigation was emphasized on the fabrication of lipid vesicular entrapped bioactive compounds as biodegradable two dimensional scaffolds using biomaterial for enhancement of intracellular uptake in immortal keratinocyte cell and its anti-inflammatory responses on lipopolysaccharides-stimulated macrophage cells. Dr. Singh has authored several technical books and book chapters and 200 plus research/review papers in reputed peer-reviewed journals. He has registered 6 patents on his credit. He is working as reviewer of various international journals. He has eleven years of teaching experience in undergraduate and postgraduate courses of pharmacy with more than six years of postdoctoral research experience. He has guided several undergraduate and postgraduate students in their project work. He is a life member of professional bodies such as the Society of Pharmacovigilance India and a registered pharmacist at the State Pharmacy Council of Chhattisgarh, India.

Dr. Popat Mohite is a distinguished academician and researcher in the field of pharmaceutical sciences. He currently serves as the Associate Professor and Head of the Department at St. John Institute of Pharmacy and Research, Palghar, Maharashtra, India. With an impressive teaching career spanning over 18 years, he has made significant contributions to both academia and research. Throughout his career, he has demonstrated a strong commitment to scientific advancement and innovation. He has authored and co-authored over 150 plus research and review articles in prestigious national and international journals, and 30 plus book chapters reflecting his expertise and active engagement in cutting-edge pharmaceutical research. In addition to his prolific publication record, Dr. Mohite has secured research grants from the University of Pune, showcasing his ability to lead and manage funded research projects. He has mentored several postgraduate students, guiding them in their academic and research endeavours. His dedication to nurturing young minds and fostering research culture among students has been one of the cornerstones of his academic career. Dr. Mohite is also an inventor, with 2 plus patents, underscoring his innovative contributions to pharmaceutical formulation and drug development. In recognition of his outstanding work, Dr. Mohite has been honoured with several prestigious awards, including the Young Researcher Award, Young Scientist Award, and Young Faculty Award.

Dr. Deepanjan Datta is currently working as an Assistant Professor at Manipal College of Pharmaceutical Sciences, Department of Pharmaceutics, Manipal Academy of Higher Education. In the year 2022, he pursued his Ph.D. in Pharmaceutics at Birla Institute of Technology and Sciences, India. During this period, he has worked extensively in the drug delivery field, including topical or transdermal and ocular drug delivery. He has also developed microneedle, contact lenses containing a peptide for the first time. Also, he has fabricated biomedical adhesive devices for enhanced transdermal drug delivery using ionic liquids. He has also developed peptide gel formulations for the Defense Research and Development Organization (DRDO). He has also received a seed grant from the Incubation Centre of Bio-Nest NIPER Guwahati and Manipal College of Pharmaceutical Sciences for the acceptance of his research proposal. Taken together, he has published a decent number of articles and has filed 10 plus patents based on research ideation. In the year 2019, he was awarded the Young Scientist award by the Controlled Release Society in recognition of his excellent contributions to the field of controlled release. His experience includes working at Dr. Reddy’s Laboratories, Hyderabad, as a formulation and research scientist in the topical and transdermal division. He is also a peer-reviewer of various SCI journals.