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Bone and Development

Felix Bronner

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ISBN 10: 1848828217 / ISBN 13: 9781848828216
Editore: Springer-Verlag Gmbh Jan 2011, 2011
Nuovi Condizione: Neu Buch
Da Rhein-Team Lörrach Ivano Narducci e.K. (Lörrach, Germania)

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Neuware - This book, Vol. 6 in the series Topics in Bone Biology, deals with bone develop ment from growth to mineralization. Understanding tissue dev- opment involves combining embryological and histological information with the increasing knowledge from molecular and genetic studies. In each developmental stage, some genes are expressed and others silenced. Disease, especially disease progression, also is characterized by changes in gene expression that then are transmitted to daughter cells. In both situations, the choreography of gene expression and partial or complete silencing often are the result of the interaction between the genome and the epi- nome, i.e., between a very stable set of structures and rapidly changing environmental factors. Chapter 1, by O Connor, Farach-Carson, and Schanen, is an overview of the feld and of topics discussed in greater detail in subsequent chapters. After discussing bone development in terms of intramembranous and en- chondral ossifcation, the chapter describes gene expression in osteoblasts and osteoclasts, bone cell coupling, and the regulatory effects of steroid h- mones. Primary genetic defects that lead to various bone diseases Marfan s syndrome, Paget s disease, and juvenile osteoporosis, among others are analyzed. The chapter ends with a section on the epigenetic regulation of bone development, including methylation, histone modifcations, and imprinting. This chapter, like all others, has an extensive bibliography and fgures to illustrate principal points. 305 pp. Englisch. Codice inventario libreria 9781848828216

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Titolo: Bone and Development

Casa editrice: Springer-Verlag Gmbh Jan 2011

Data di pubblicazione: 2011

Legatura: Buch

Condizione libro:Neu

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This is a sixth volume in a series of reviews, centered on a single major topic within the field of osteopathy. The book is an appropriate mechanism for advancing knowledge in the field to researchers, clinicians and others involved in the bone field.This work intends to look at the role bone development within the field of pediatrics, covering all problematic aspects from basic skeletal growth to tooth mineralization.To understand tissue development requires combining embryological and histological knowledge with the increasing information becoming available from molecular and genetic studies. Development is characterized by the expression of genes, their subsequent silencing and the expression of other genes. Disease, especially disease progression, is equally characterized by new gene expression that is then transmitted to daughter cells, with the silencing of other genes. In both instances these sequences are the result of the interaction between the genome and the epigenome, i.e. between a very stable set of structures and rapidly changing environmental factors.

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