Boolean Networks as Predictive Models of Emergent Biological Behaviors (Paperback)

Jordan C. Rozum

ISBN 10: 100929296X / ISBN 13: 9781009292962

Editore: Cambridge University Press, Cambridge, 2024

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Paperback. Interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions from molecules in gene regulatory networks to species in ecological networks and the often-incomplete state of system knowledge, such as the unknown values of kinetic parameters for biochemical reactions. Boolean networks have emerged as a powerful tool for modeling these systems. This Element provides a methodological overview of Boolean network models of biological systems. After a brief introduction, the authors describe the process of building, analyzing, and validating a Boolean model. They then present the use of the model to make predictions about the system's response to perturbations and about how to control its behavior. The Element emphasizes the interplay between structural and dynamical properties of Boolean networks and illustrates them in three case studies from disparate levels of biological organization. This Element shows interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions and the often-incomplete state of system knowledge. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Codice articolo 9781009292962

Dati bibliografici

• Titolo: Boolean Networks as Predictive Models of Emergent Biological Behaviors (Paperback)
• Editore: Cambridge University Press, Cambridge
• Data di pubblicazione: 2024
• Lingua: Inglese
• ISBN 10: 100929296X
• ISBN 13: 9781009292962
• Rilegatura: Paperback
• Condizione: new

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Riassunto

Interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions – from molecules in gene regulatory networks to species in ecological networks – and the often-incomplete state of system knowledge, such as the unknown values of kinetic parameters for biochemical reactions. Boolean networks have emerged as a powerful tool for modeling these systems. This Element provides a methodological overview of Boolean network models of biological systems. After a brief introduction, the authors describe the process of building, analyzing, and validating a Boolean model. They then present the use of the model to make predictions about the system's response to perturbations and about how to control its behavior. The Element emphasizes the interplay between structural and dynamical properties of Boolean networks and illustrates them in three case studies from disparate levels of biological organization.