CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

Lingua: inglese

Editore: Springer, 2005

3540244441 / 9783540244448

Serie: Libro 9 di 322 - Current Topics in Microbiology and Immunology

Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

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Druck auf Anfrage Neuware - Printed after ordering - The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-reactive T cells via negative selection in the thymus dominant tolerance exerted by regulatory T cells plays a major role in tolerance imposition and maintenance. Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called 'natural' regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues. The repertoire of Treg is clearly biased towards recognition of self-antigens, thereby potentially preventing autoimmune diseases such as gastritis and oophoritis. Regulatory T cells, however also control infections, allergies and tolerance to transplanted tissues and this requires their induction in the periphery under conditions which are not yet fully understood. The concept of dominant tolerance, by far not novel, will offer new insights and hopefully tools for the successful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival. The fulfillment of these high expectations will, however, require their unambiguous identification and a better understanding of their mode of action.

Codice articolo 9783540244448

Titolo
CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
Autore
B. Kyewski
Editore
Springer
Anno di pubblicazione
2005
Condizione
Neu
Rilegatura
Buch
Lingua
inglese
ISBN 10
3540244441
ISBN 13
9783540244448
Peso dell'articolo
745 grammi
Dimensioni
241x160x26 mm
Serie
Libro 9 di 322: Current Topics in Microbiology and Immunology

AHA-BUCH GmbH

Einbeck, Germania

Venditore con 5 stelle

Venditore AbeBooks dal 14 agosto 2006

Tariffe di spedizione da Germania a U.S.A.

ArticoloDa 5 a 7 giorni lavorativiDa 7 a 10 giorni lavorativi
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