CRC Handbook of Laboratory Safety: Fourth Edition

This Fourth Edition of the CRC Handbook of Laboratory Safety expands and updates the discussions found in the previous editions. The latest technologies and issues are incorporated to keep managers and laboratory personnel up-to-date on effective programs to meet the needs of new regulations.
Since the publication of the previous edition, the anticipated realization of numerous standards has become fact. The present edition contains material on all of these.
Every attempt has been made to ensure that the current edition is as up-to-date as possible by continually reviewing current regulatory standards. Every article has been revised to reflect the newest changes. Topics may be similar but the content may have changed significantly. The wealth of information easily accessible in this new edition continues to make the CRC Handbook of Laboratory Safety an essential reference tool.
The Fourth Edition covers the numerous actions that have significant impact on laboratory safety, including:

New OSHA laboratory safety standards

1994 NRC radiation safety standards

Guidelines for X-ray use in hospitals

Enforcement of the standard for dealing with blood-borne pathogens, including the Ryan White Act

Changes in DOT regulations on the packaging of hazardous materials

EPA action on the release of radioactive materials into the environment

OSHA actions covering hazardous waste operations and emergency response

New CDC guidelines for research with microbiological hazards

Introduction
Laboratory Safety as a Cooperative Responsibility
Organizational Structure
The Safety Department
Departmental Responsibilities
Laboratory Responsibilities
References
Emergencies
Components of Emergency Preparedness
Initial Conditions. Facilities, Fixed and Movable Equipment
Institutional or Corporate Emergency Committee
Emergency Plan
Laboratory Emergency Plan. Organizational Emergency Plan. Emergency Equipment. Basic Emergency Procedures. Emergency Procedures for Selected Emergencies. Artificial Respiration, Cardiopulmonary Resuscitation (CPR), and First Aid
Laboratory Facilities-Design and Equipment
Laboratory Design
Engineering and Architectural Principles. Building Codes and Regulatory Requirements. Laboratory Classification. Access. Construction and Interior Finish. Ventilation. Electrical Systems. Plumbing. Other Laboratory Utilities. Maintenance Factors.
Fixed Equipment and Furniture
Laboratory Furniture. Hoods. Built-In Safety Equipment. Other Fixed Equipment
Chemical Storage Rooms
Capacity. Construction Features. Ventilation. Fire Safety.
Movable Equipment
Refrigeration Equipment. Ovens. Heating Baths. Stills. Kjeldahl Systems. Autoclaves.
Animal Laboratories Special Requirements
Fixed Equipment in Animal Holding Facilities. Equipment for Animal Laboratories and Holding Areas. Appendix: Vertebrate Animal Safety Boisafety Level Criteria.
Laboratory Operations
General Considerations
OSHA Laboratory Safety Standard
The Chemical Laboratory. Chemical Hygiene Plan
Operational Planning
Quantities. Sources. Material Safety Data Sheets. Purchase of Regulated Items. Free Materials
Purchasing of Animals
Storage
Compatible Chemical Storage. Labeling. Regulated Materials. Ethers. Perchloric Acid. Flammable Liquids. Refrigeration Storage. Gas Cylinders. Animal Food and Supply Storage.
Handling and Use of Chemicals in Laboratory Operations
Physical Laboratory Conditions. Working Procedures.
Hazard Awareness (Right-to-Know)
Basic Requirements. Written Hazard Communication Program.
Health Effects
Exposure Limits. Environmental Monitoring. Modes of Exposure. Health Assurance Program. The OSHA Blood-borne Pathogen Standard: Infection from Work with Human Specimens. Pregnancy in the Laboratory. Regulated and Potential Carcinogens. Neurological Hazards of Solvents.
Spills and Emergencies
Small-to Moderate-Scale Spills. Large-Scale Releases of Chemicals.
Chemical Wastes
Resource Conservation and Recovery Act. Practical Hazardous Waste Management Program.
State-of-the-Art Hospital and Institutional Waste Incineration, Selection, Procurement, and Operations
Laboratory Closeout Procedures
Nonchemical Laboratories
Introduction
Radioisotope Laboratories
Natural Radioactivity. Basic Concepts. Licensing. Radiation Protection, Discussion, and Definitions. Radioisotope Facilities and Practices. Material Control Procedures. Operations. Radon. Acute Radiation Syndrome.
X-Ray Facilities
Generation of X-Rays. Types of Machines
Non-Ionizing Radiation
Guidelines on Limits of Exposure to Radiofrequency Electromagnetic Fields in the Frequency Range From 100 kHz to 300 GHz
Laser Laboratories
Protective Procedures for Class IIIb and Class IV Lasers. Eye Protection. Medical Surveillance.
Microbiological and Biomedical Laboratories
Introduction. Laboratory Safety and Hazard Communication Standards. Laboratory Director. Miscellaneous Safety Practices. Accidents and Spills of Biohazardous Materials. Generation of Aerosols. Infectious Waste. Laboratory Facilities-Design and Equipment. Biosafety Levels. Recommended Biosafety Levels.
Recombinant DNA Laboratories
Definition of Recombinant DNA Molecules. General Applicability. Containment. Guidelines in Covered Experiments. Roles and Responsibilities. Appendices.
Research Animal Care and Handling
Introduction. Laws and Regulations Relating to Animal Care and Use. Personnel. Animal Holding Facilities. Animal Care and Handling. Human Health Monitoring.
Personal Protective Equipment
Introduction
Respiratory Protection
Eye Protection
Materials for Protective Apparel
Hearing Protection
First Aid Kits
References
Appendix: Laboratory Checklist
Index