Calcium and Ion Channel Modulation

Lingua: inglese

Editore: Springer, Springer Sep 2011, 2011

146128273X / 9781461282730

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This item is printed on demand - Print on Demand Titel. Neuware -Cellular neurobiology has been transformed in the past decade by new technologies and fundamental discoveries. One result is an enormous increase in our understanding of how ion channels function in nerve and muscle cells and a widening perspective on the role of ion channels in non-neuronal cell physiology and development. Patch clamp techniques now permit direct observation of the transitions between functional confor mations of individual ion channels in their native membrane. Recombinant DNA techniques are being used to determine the primary structure of ion channel proteins and to test hypotheses about channel conformations, sites of grating and modulation, and the basis of ion selectivity. At the same time, biochemical techniques have revealed intricate signalling systems in side cells, involving second messengers such as calcium, phospholipids and cyclic nucleotides, which interface with the external milieu through GTP binding proteins and regulate cell metabolism by altering protein phos phorylation. This panorama of second messenger systems has greatly increas ed our application for their potential role in regulating ion channel function. We now recognize that ion channels are much more complicated than we once thought, and more interesting. They are not simply isolated macro molecules in the membrane, gated directly by depolarization or trans mitter binding to open briefly at a fixed conductance and then close or inactivate. Instead, individual channels now appear to have many open and closed states that are regulated independently by voltage and transmitters.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 464 pp. Englisch.…

Codice articolo 9781461282730

Titolo
Calcium and Ion Channel Modulation
Autore
A. D. Grinnell
Editore
Springer, Springer Sep 2011
Anno di pubblicazione
2011
Condizione
Neu
Rilegatura
Taschenbuch
Lingua
inglese
ISBN 10
146128273X
ISBN 13
9781461282730
Peso dell'articolo
794 grammi
Dimensioni
244x170x25 mm

buchversandmimpf2000

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